VWC2

VWC2 is BMP antagonist which may play a role in neural development. VWC2 promotes cell adhesion .

VWC2 Alternative Names

VWC2, UNQ739/PRO1434, MGC131845, PSST739, UNQ739 [Homo sapiens]

Vwc2, RP23-305B2.1, A930041G11Rik, PSST739, UNQ739, cradin [Mus musculus]

Summaries for VWC2

Entrez Gene summary for VWC2:

VWC2 gene encodes a secreted bone morphogenic protein antagonist. The encoded protein is possibly involved in neural function and development and may have a role in cell adhesion.[provided by RefSeq, Oct 2009]

Wikipedia summary for VWC2:

Von Willebrand factor, type C is a protein domain is found in various blood plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII, XII and XIV; and other extracellular proteins.
Although the majority of VWA-containing proteins are extracellular, the most ancient ones present in all eukaryotes are all intracellular proteins involved in functions such as transcription, DNA repair, ribosomal and membrane transport and the proteasome.
A common feature appears to be involvement in multiprotein complexes. Proteins that incorporate vWF domains participate in numerous biological events (e.g. cell adhesion, migration, homing, pattern formation, and signal transduction), involving interaction with a large array of ligands. A number of human diseases arise from mutations in VWA domains.
The domain is named after the von Willebrand factor (VWF) type C repeat which is found in multidomain protein/multifunctional proteins involved in maintaining homeostasis. For the von Willebrand factor the duplicated VWFC domain is thought to participate in oligomerization, but not in the initial dimerization step. The presence of this region in a number of other complex-forming proteins points to the possible involvement of the VWFC domain in complex formation.

Human VWC2 Protein General Information

 

• Protein names: von Willebrand factor C domain-containing protein 2
  Short name=VWC2
• Sequence length: 325 AA.
• Domain: Repeat
  Signal
• Sequence similarities: Contains 2 VWFC domains.
• Subcellular location: Secreted › extracellular space › extracellular matrix › basement membrane

General information above from UniProt

Function for VWC2 Protein

UniProtKB:

VWC2 is BMP antagonist which may play a role in neural development. VWC2 promotes cell adhesion .

Genatlas:

• VWC2 is potentially involved in neural development (Miyake 2009)
• VWC2 is novel secreted BMP antagonist that potentially plays roles in neural development and functions (Koike 2007)