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VWC2 Antibody, Rabbit PAb

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Human VWC2 Antibody Product Information
Immunogen:Recombinant Human VWC2 protein (Catalog#12071-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human VWC2 (rh VWC2; Catalog#12071-H08H; NP_055747.1; Met 1-Met 325). Total IgG was purified by Protein A affinity chromatography.
Human VWC2 Antibody Usage Guide
Specificity:Human VWC2
Application:ELISA

ELISA: 0.5-1 μg/mL

This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human VWC2. The detection limit for Human VWC2 is approximately 0.00975 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other VWC2 Antibody Products
Reactivity: Human  
Application: ELISA  
    12071-MM06-200
    12071-MM06-50
    12071-MM06-100
    200 µg 
    50 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  IHC-P  
    • Slide 1
    12071-RP02-200
    12071-RP02-50
    12071-RP02-100
    200 µg 
    50 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      12071-R044-50
      12071-R044-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        12071-MM01-200
        12071-MM01-100
        12071-MM01-50
        200 µg 
        100 µg 
        50 µg 
        Add to Cart
        VWC2 Background

        Brorin, also known as brain-specific chordin-like protein, von Willebrand factor C domain-containing protein 2 and VWC2, is a secreted protein which contains two VWFC domains. VWC2 / Brorin is a BMP antagonist which may play a role in neural development. It promotes cell adhesion. VWC2 / Brorin is a unique member of the chordin family. It inhibited the activity of bone morphogenetic protein 2 (BMP2) and BMP6 in mouse preosteoblastic MC3T3-E1 cells. Mouse Brorin was predominantly expressed in neural tissues in embryos and also predominantly expressed in the adult brain. In the brain, the expression was detected in neurons, but not glial cells. The neural tissue-specific expression profile of Brorin is quite distinct from that of any other member of the Chordin family. VWC2 / Brorin protein promoted neurogenesis, but not astrogenesis, in mouse neural precursor cells. VWC2 / Brorin is a novel secreted BMP antagonist that potentially plays roles in neural development and functions.

        Human VWC2 References
      • Koike,N. et al., 2007, J Biol Chem. 282 (21):15843-50.
      • Elis,S. et al., 2009,Mol Reprod Dev. 76 (11):1043-55.
      • Zhang,J.L. et al., 2010,PLoS One. 5 (9):e12846.
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        Size / Price
        Catalog: 12071-RP01-400
        List Price: 
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        All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
        Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"