Anti-VWC2 Antibody

Cat: 12071-MM06
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Anti-VWC2 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-VWC2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human VWC2
No cross-reactivity with Human cell lysate (293 cell line) in ELISA.
Immunogen
Recombinant Human VWC2 Protein (Catalog#12071-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human VWC2 (rh VWC2; Catalog#12071-H08H; NP_055747.1; Met 1-Met 325). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG2a Clone #3H2A1
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-VWC2 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-VWC2 Antibody Alternative Names
Anti-PSST739 Antibody;Anti-UNQ739 Antibody
VWC2 Background Information

Brorin, also known as brain-specific chordin-like protein, von Willebrand factor C domain-containing protein 2 and VWC2, is a secreted protein which contains two VWFC domains. VWC2 / Brorin is a BMP antagonist which may play a role in neural development. It promotes cell adhesion. VWC2 / Brorin is a unique member of the chordin family. It inhibited the activity of bone morphogenetic protein 2 (BMP2) and BMP6 in mouse preosteoblastic MC3T3-E1 cells. Mouse Brorin was predominantly expressed in neural tissues in embryos and also predominantly expressed in the adult brain. In the brain, the expression was detected in neurons, but not glial cells. The neural tissue-specific expression profile of Brorin is quite distinct from that of any other member of the Chordin family. VWC2 / Brorin protein promoted neurogenesis, but not astrogenesis, in mouse neural precursor cells. VWC2 / Brorin is a novel secreted BMP antagonist that potentially plays roles in neural development and functions.

Full Name
von Willebrand factor C domain containing 2
References
  • Koike,N. et al., 2007, J Biol Chem. 282 (21):15843-50.
  • Elis,S. et al., 2009,Mol Reprod Dev. 76 (11):1043-55.
  • Zhang,J.L. et al., 2010,PLoS One. 5 (9):e12846.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-VWC2 Antibody Rabbit Polyclonal ELISA 12071-RP01
    Anti-VWC2 Antibody Mouse Monoclonal ELISA 12071-MM01
    Anti-VWC2 Antibody Mouse Monoclonal ELISA(Det) 12071-MM03
    Anti-VWC2 Antibody Mouse Monoclonal ELISA(Cap) 12071-MM08
    Anti-VWC2 Antibody Rabbit Monoclonal ELISA 12071-R044
    Anti-VWC2 Antibody Rabbit Polyclonal ELISA,IHC-P 12071-RP02
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