VSIG4

VSIG4 is phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. VSIG4 is potent inhibitor of the alternative complement pathway convertases.

VSIG4 Related Areas

Immunology>>Innate Immunity>>Complement System>>VSIG4

VSIG4 Alternative Names

VSIG4, Z39IG, CRIg, RP6-159A1.1 [Homo sapiens]

Vsig4, Z39IG, CRIg, RP23-23B17.3, A530061A11, BC025105, MGC36211 [Mus musculus]

Summaries for VSIG4

Entrez Gene summary for VSIG4:

VSIG4 gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Human VSIG4 Protein General Information

 

• Protein names: V-set and immunoglobulin domain-containing protein 4
  Short name=VSIG4
• Sequence length: 399 AA.
• Domain: Immunoglobulin domain
  Repeat
  Signal
  Transmembrane
  Transmembrane helix
• Sequence similarities: Contains 2 Ig-like (immunoglobulin-like) domains.
• Subcellular location: Membrane; Single-pass type I membrane protein
• Tissue specificity: Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung and placenta. Expressed in resting macrophages.

General information above from UniProt

Function for VSIG4 Protein

UniProtKB:

VSIG4 is phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. VSIG4 is potent inhibitor of the alternative complement pathway convertases.