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VSIG4  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
  • Slide 1
12163-H08H-50
12163-H08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
12163-H02H-50
12163-H02H-100
50 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
50187-M03H-50
50187-M03H-100
50 µg 
100 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
50187-M08H-50
50187-M08H-100
50 µg 
100 µg 
Add to Cart

VSIG4 Related Pathways

    VSIG4 Summary & Protein Information

    VSIG4 Background

    Gene Summary: VSIG4 gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
    General information above from NCBI
    Subcellular location: Membrane; Single-pass type I membrane protein (Probable).
    Tissue specificity: Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung and placenta. Expressed in resting macrophages.
    Sequence similarity: Contains 2 Ig-like (immunoglobulin-like) domains.C
    General information above from UniProt

    VSIG4 (V-set and immunoglobulin domain containing 4), also known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig, is a type I  transmembrane glycoprotein. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that are covalently attached to particle surfaces. No VSIG4 expression appears to be present in T and B cells. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. Mouse VSIG4 is synthesized as a 280 amino acid precursor that contains a signal sequence, an V-type I g domain (aa 36-115), one potential N-linked glycosylation site, and a single transmembrane domain. The V-type I g domain of mouse VSIG4 shares 86% and 80% aa sequence identity with the V-type I g domains of rat and human VSIG4, respectively.

    VSIG4 Alternative Name

    CRIg,Z39IG, [homo-sapiens]
    CRIg,RP6-159A1.1,VSIG4,Z39IG, [human]
    A530061A11,BC025105,CRIg,MGC36211,RP23-23B17.3,Vsig4,Z39IG, [mouse]
    CRIg,Z39IG,BC025105,A530061A11, [mus-musculus]

    VSIG4 Related Studies

  • Vogt, L. et al., 2006, J Clin Invest.116: 2817-2826.
  • Helmy, K. et al., 2006, Cell. 124:915-927.
  • Wiesmann, C. et al., 2006, Nature. 444:217-220.
  • Zang,X. et al., 2006, J Clin Invest. 116: 2590-2593.
  • Katschke, KJ. et al., 2007, J. Exp. Med. 204:1319-1325.
  • He,JQ. et al., 2008, Mol Immunol. 45: 4041-4047.
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