Anti-VSIG4 Antibody

Cat: 50187-RP01
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Anti-VSIG4 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-VSIG4 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse VSIG4
Immunogen
Recombinant Mouse VSIG4 protein (Catalog#50187-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse VSIG4 extracellular domain (rM VSIG4; Catalog#50187-M08H; NP_808457.1; Met 1-Pro 187). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-VSIG4 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-VSIG4 Antibody Alternative Names
Anti-A530061A11 Antibody;Anti-BC025105 Antibody;Anti-CRIg Antibody;Anti-Z39IG Antibody
VSIG4 Background Information

VSIG4 (V-set and immunoglobulin domain containing 4), also known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig, is a type I  transmembrane glycoprotein. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that are covalently attached to particle surfaces. No VSIG4 expression appears to be present in T and B cells. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. Mouse VSIG4 is synthesized as a 280 amino acid precursor that contains a signal sequence, an V-type I g domain (aa 36-115), one potential N-linked glycosylation site, and a single transmembrane domain. The V-type I g domain of mouse VSIG4 shares 86% and 80% aa sequence identity with the V-type I g domains of rat and human VSIG4, respectively.

Full Name
V-set and immunoglobulin domain containing 4
References
  • Vogt, L. et al., 2006, J Clin Invest.116: 2817-2826.
  • Helmy, K. et al., 2006, Cell. 124:915-927.
  • Wiesmann, C. et al., 2006, Nature. 444:217-220.
  • Zang,X. et al., 2006, J Clin Invest. 116: 2590-2593.
  • Katschke, KJ. et al., 2007, J. Exp. Med. 204:1319-1325.
  • He,JQ. et al., 2008, Mol Immunol. 45: 4041-4047.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-VSIG4 Antibody Rabbit Polyclonal ELISA 50187-RP02
    Anti-VSIG4 Antibody Rabbit Polyclonal ELISA 50187-T16
    Anti-VSIG4 Antibody Rabbit Polyclonal ELISA 12163-RP02
    Anti-VSIG4 Antibody Rabbit Monoclonal ELISA,ELISA(Det) 12163-R005
    Anti-VSIG4 Antibody Mouse Monoclonal ELISA 12163-MM03
    Anti-VSIG4 Antibody Rabbit Monoclonal ELISA(Cap) 12163-R202
    Anti-VSIG4 Antibody Rabbit Polyclonal ELISA 12163-RP01
    Anti-VSIG4 Antibody Rabbit Polyclonal ELISA,IHC-P 12163-T24
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