VNN2 (Vanin-2)

VNN2 is amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. VNN2 is involved in the thymus homing of bone marrow cells. VNN2 may regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.

VNN2 (Vanin-2) Related Areas

Enzyme>>Oxidoreductase>>VNN2/Vanin-2

VNN2 (Vanin-2) Alternative Names

VNN2, Vanin-2, Vanin 2, FOAP-4, GPI-80 [Homo sapiens]

Summaries for VNN2 (Vanin-2)

Entrez Gene summary for VNN2 (Vanin-2):

VNN2 gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. VNN2 gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for VNN2 gene. [provided by RefSeq, May 2011]

Wikipedia summary for VNN2 (Vanin-2):

Vascular non-inflammatory molecule 2 is a protein that in humans is encoded by the VNN2 gene.
This gene product is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Two transcript variants encoding different isoforms have been described for this gene.

Human VNN2 (Vanin-2) Protein General Information

 

• Protein names: Vascular non-inflammatory molecule 2
  Short name=Vanin-2
• Sequence length: 520 AA.
• Domain: Signal
• Sequence similarities: Belongs to the CN hydrolase family. BTD/VNN subfamily.
  Contains 1 CN hydrolase domain.
• Catalytic activity: (R)-pantetheine + H₂O = (R)-pantothenate + 2-aminoethanethiol.
• Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor.
• Tissue specificity: widely expressed with higher expression in spleen and blood.

General information above from UniProt

Function for VNN2 (Vanin-2) Protein

UniProtKB:

VNN2 is amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. VNN2 is involved in the thymus homing of bone marrow cells. VNN2 may regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.

Genatlas:

• VNN2 is involved in lymphocyte migration and cell adhesion
• VNN2 is pantetheinase activity playing a role in oxidative-stress response
• VNN2 plays a role in transendothelial migration of neutrophils
• VNN2 is involved in the thymus homing of bone marrow cells
• VNN2 is ectoenzyme
• VNN2 is modulator of beta2 integrin functions (Nitto 2008)

Homology for human VNN2 (Vanin-2)

• homolog to murine Vnn1,Vnn2
• homolog to Drosophila Cg3599
• homolog to rattus Vnn3 (61.5pc)
• homolog to murine Vnn3 (61.7pc)
• homolog to Biotinidase