VNN1 (Vanin-1)

Pantetheinase, also known as Pantetheine hydrolase, Vascular non-inflammatory molecule 1, Vanin-1, and VNN1, is a cell membrane protein which belongs to the CN hydrolase family and BTD/VNN subfamily. Vanin-1 contains one CN hydrolase domain. It is widely expressed with higher expression in spleen, kidney and blood. It is overexpressed in lesional psoriatic skin. Vanin-1 is also a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. Vanin-1 is an epithelial pantetheinase that provides cysteamine to tissue and regulates response to stress. Vanin-1 is expressed by enterocytes, and its absence limits intestinal epithelial cell production of proinflammatory signals. Vanin-1 regulates late adhesion steps of thymus homing under physiological, noninflammatory conditions. The early impact of vanin-1 deficiency on tumor induction was directly correlated to the amount of inflammation and subsequent epithelial proliferation rather than cell death rate. Vanin-1 molecule was shown to be involved in the control of thymus reconstitution following sublethal irradiation.

VNN1 (Vanin-1) Related Areas

Cardiovascular>>Blood Pressure Regulation>>VNN1/Vanin-1

Enzyme>>Oxidoreductase>>VNN1/Vanin-1

VNN1 (Vanin-1) Alternative Names

VNN1, vanin-1, pantetheinase, vannin 1, HDLCQ8, MGC116930, MGC116931, MGC116932, MGC116933, Tiff66, pantetheine hydrolase, vascular non-inflammatory molecule 1 [Homo sapiens]

Vnn1, vanin-1, pantetheinase, pantetheine hydrolase, V-1, vascular non-inflammatory molecule 1 [Mus musculus]

Summaries for VNN1 (Vanin-1)

Entrez Gene summary for VNN1 (Vanin-1):

VNN1 gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]

Wikipedia summary for VNN1 (Vanin-1):

Pantetheinase is an enzyme that in humans is encoded by the VNN1 gene.
This gene product is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24.

Human VNN1 (Vanin-1) Protein General Information

 

• Protein names: Vascular non-inflammatory molecule 1
  Short name=Vanin-1
• Sequence length: 513 AA.
• Domain: Signal
• Sequence similarities: Belongs to the CN hydrolase family. BTD/VNN subfamily.
  Contains 1 CN hydrolase domain.
• Catalytic activity: (R)-pantetheine + H₂O = (R)-pantothenate + 2-aminoethanethiol.
• Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor
• Tissue specificity: Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin.

General information above from UniProt

Function for VNN1 (Vanin-1) Protein

UniProtKB:

VNN1 is amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.

Genatlas:

• VNN1 is involved in lymphocyte migration in cell adhesion and in the colonization of the thymus by hematopoietic precursor cells
• VNN1 is regulation of Sertoli cells
• VNN1 is pantetheinase activity playing a role in oxidative-stress response
• VNN1 hydrolyzes specifically one of carboamide linkages in D-pantetheinase thus recycling pantothenic acid
• VNN1 is ectoenzyme

Homology for human VNN1 (Vanin-1)

• ortholog to murine Vnn1
• ortholog to Drosophila Vanin-like
• homolog to biotinidase

Phenotype Information for VNN1 (Vanin-1)

• Gene/Locus: VNN1, HDLCQ8
• Phenotype: [High density lipoprotein cholesterol level QTL 8]

Phenotype Information for VNN1 (Vanin-1) from OMIM (Online Mendelian Inheritance in Man)