VNN1 / Vanin-1 Protein (Pantetheinase)

VNN1 / Vanin-1 Products

VNN1 / Vanin-1 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
VNN1/Vanin-1	Human	VNN1/Vanin-1 Protein, Recombinant	11662-H08H
VNN1/Vanin-1	Mouse	Mouse Vanin-1 / VNN1 Protein, Recombinant	50952-M08H

VNN1 / Vanin-1 Antibody

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
VNN1/Vanin-1	Mouse	PPM1A / PP2C-alpha Antibody	50277-RP01
VNN1/Vanin-1	Mouse	PPM1A / PP2C-alpha Antibody (Antigen Affinity Purified)	50277-RP02

VNN1 / Vanin-1 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
VNN1/Vanin-1	Human	Homo sapiens VNN1/Vanin-1 cDNA Clone	HG11662-M
VNN1/Vanin-1	Mouse	Mouse VNN1/Vanin-1 cDNA gene Clone / ORF gene clone	MG50952-G

VNN1 / Vanin-1 Related Areas

Cardiovascular>>Blood Pressure Regulation>>VNN1/Vanin-1

Enzyme>>Oxidoreductase>>VNN1/Vanin-1

VNN1 / Vanin-1 Alternative Names

VNN1, vanin-1, pantetheinase, vannin 1, HDLCQ8, MGC116930, MGC116931, MGC116932, MGC116933, Tiff66, pantetheine hydrolase, vascular non-inflammatory molecule 1 [Homo sapiens]

Vnn1, vanin-1, pantetheinase, pantetheine hydrolase, V-1, vascular non-inflammatory molecule 1 [Mus musculus]

VNN1 / Vanin-1 Background

Pantetheinase, also known as Pantetheine hydrolase, Vascular non-inflammatory molecule 1, Vanin-1, and VNN1, is a cell membrane protein which belongs to the CN hydrolase family and BTD/VNN subfamily. Vanin-1 contains one CN hydrolase domain. It is widely expressed with higher expression in spleen, kidney and blood. It is overexpressed in lesional psoriatic skin. Vanin-1 is also a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. Vanin-1 is an epithelial pantetheinase that provides cysteamine to tissue and regulates response to stress. Vanin-1 is expressed by enterocytes, and its absence limits intestinal epithelial cell production of proinflammatory signals. Vanin-1 regulates late adhesion steps of thymus homing under physiological, noninflammatory conditions. The early impact of vanin-1 deficiency on tumor induction was directly correlated to the amount of inflammation and subsequent epithelial proliferation rather than cell death rate. Vanin-1 molecule was shown to be involved in the control of thymus reconstitution following sublethal irradiation.

VNN1 / Vanin-1 Related Studies

1. Aurrand-Lions M, et al. (1996) Vanin-1, a Novel GPI-Linked Perivascular Molecule Involved in Thymus Homing. Immunity. 5 (5): 391-405.
2. Grimmond S, et al. (2000) Sexually dimorphic expression of protease nexin-1 and vanin-1 in the developing mouse gonad prior to overt differentiation suggests a role in mammalian sexual development. Hum Mol Genet. 9 (10): 1553-60.
3. Meghari S, et al. (2007) Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection. Eur J Immunol. 37 (1): 24-32.