All VLDL Receptor reagents are produced in house and quality controlled, including 4 VLDL Receptor Antibody, 12 VLDL Receptor Gene, 1 VLDL Receptor Lysate, 1 VLDL Receptor Protein, 1 VLDL Receptor qPCR. All VLDL Receptor reagents are ready to use.
Recombinant VLDL Receptor proteins are expressed by HEK293 Cells with fusion tags as C-His.
VLDL Receptorantibodies are validated with different applications, which are ELISA, WB.
VLDL ReceptorcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each VLDL Receptor of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
The very low density lipoprotein receptor, known as VLDLR, is a single-pass type 1 integral membrance protein and a member of the LDL receptor family. This receptor family includes LDL receptor, LRP, megalin, VLDLR and ApoER2, and is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. VLDLR contains 3 EGF-like domains, 8 LDL-receptor class A domains, as well as 6 LDL-receptor class B repeats, and is abundant in heart, skeletal muscle, also ovary and kidney, but not in liver. VLDLR binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. VLDLR mediates the phosphorylation of mDab1 (mammalian disabled protein) via binding to Reelin, and induces the modulation of Tau phosphorylation. This pathway regulates the migration of neurons along the radial glial fiber network during brain development. Defects of VLDLR may be the cause of VLDLR-associated cerebellar hypoplasia (VLDLRCH), a syndrome characterized by moderate-to-profound mental retardation, delayed ambulation, and predominantly truncal ataxia.