Anti-VLDL Receptor Antibody

Cat: 11075-RP02
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Anti-VLDL Receptor Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-VLDL Receptor Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human VLDL Receptor
Immunogen
Recombinant Human VLDLR protein (Catalog#11075-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human VLDLR (rh VLDLR; Catalog#11075-H08H; NP_003374.3; Met 1-Ser 797). VLDLR specific IgG was purified by human VLDLR affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-VLDL Receptor Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-VLDL Receptor Antibody Alternative Names
Anti-CAMRQ1 Antibody;Anti-CARMQ1 Antibody;Anti-CHRMQ1 Antibody;Anti-VLDLRCH Antibody
VLDL Receptor Background Information

The very low density lipoprotein receptor, known as VLDLR, is a single-pass type 1 integral membrance protein and a member of the LDL receptor family. This receptor family includes LDL receptor, LRP, megalin, VLDLR and ApoER2, and is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. VLDLR contains 3 EGF-like domains, 8 LDL-receptor class A domains, as well as 6 LDL-receptor class B repeats, and is abundant in heart, skeletal muscle, also ovary and kidney, but not in liver. VLDLR binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. VLDLR mediates the phosphorylation of mDab1 (mammalian disabled protein) via binding to Reelin, and induces the modulation of Tau phosphorylation. This pathway regulates the migration of neurons along the radial glial fiber network during brain development. Defects of VLDLR may be the cause of VLDLR-associated cerebellar hypoplasia (VLDLRCH), a syndrome characterized by moderate-to-profound mental retardation, delayed ambulation, and predominantly truncal ataxia.

Full Name
very low density lipoprotein receptor
References
  • Trommsdorff, M. et al., 1999. Cell. 97: 689-701.
  • Mikhailenko, I. et al., 1999. J. Cell Sci. 112: 3269-3281.
  • Sato, A. et al., 1999. Biochem. J. 341: 377-383.
  • Hiesberger, T. et al., 1999. Neuron 24: 481-489.
  • Tiebel, O. et al., 1999. Atherosclerosis 145: 239-251.
  • Boycott, K.M. et al., 2005, Am. J. Hum. Genet. 77 (3): 477-483. 
  • Moheb, L.A. et al., 2008, Eur. J. Hum. Genet. 16 (2): 270-273.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-VLDL Receptor Antibody Rabbit Monoclonal ELISA 11075-R011
    Anti-VLDL Receptor Antibody Mouse Monoclonal ELISA 11075-MM04
    Anti-VLDL Receptor Antibody Rabbit Polyclonal ELISA 11075-RP01
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