VEGFR3 / FLT-4 Protein & Antibody

Vascular Endothelial Growth Factor Receptor 3 / Fms-related tyrosine kinase 4

VEGFR3 / FLT-4 Protein & Antibody

Sino biological offers a comprehensive set of tools for vascular endothelial growth factor (VEGF) related research. These include high-purity proteins, high-specific antibodies and ORF cDNA clones.

VEGFR3 / FLT-4 Protein, Recombinant

Molecule	Species	Description	Cat. No
VEGFR3/FLT-4	Human	VEGFR3/FLT-4/Fc Protein, Recombinant	10806-H02H
VEGFR3/FLT-4	Human	VEGFR3/FLT-4 Protein, Recombinant	10806-H08H
VEGFR3/FLT-4	Mouse	VEGFR3/FLT-4/Fc Protein, Recombinant	50584-M02H
VEGFR3/FLT-4	Mouse	VEGFR3/FLT-4 Protein, Recombinant	50584-M08H

  10806-H02H:

1. Immobilized human VEGFR3/Fc chimera at 5 µg/ml (100 µl/well) can bind human VEGF-D at a linear range of 62.5-2000 ng/ml. Measured by its binding ability in a functional ELISA.

2. Immobilized recombinant human VEGF-C at 10 µg/ml (100 µl/well) can bind recombinant human VEGFR3 at a linear range of 0.64-80 ng/ml. Measured by its binding ability in a functional ELISA.

3.Scatchard analysis showed the affinity constant (Kd) of recombinant human VEGF-C bound to recombinant human VEGFR3 was 1.4 nM. Measured by its binding ability in a functional ELISA.

VEGFR3 / FLT-4 Antibody

Molecule	Application	Description	Cat. No
Human VEGFR3/FLT-4	WB	Mouse Monoclonal Antibody	10806-MM02
Human VEGFR3/FLT-4	ELISA	Mouse Monoclonal Antibody	10806-MM03
Human VEGFR3/FLT-4	ELISA	Rabbit Polyclonal Antibody	10806-RP01
Human VEGFR3/FLT-4	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10806-RP04
Mouse VEGFR3/FLT-4	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50584-RP02

VEGFR3 / FLT-4 ELISA Kit

Molecule	Application	Description	Cat. No
Human VEGFR3/FLT-4	ELISA	VEGFR3/FLT-4 ELISA Kit	SEK10806

VEGFR3 / FLT-4 cDNA clone

Molecule	Species	Description	Cat. No
VEGFR3/FLT-4	Human	Homo sapiens VEGFR3/FLT-4 cDNA Clone	HG10806-M

VEGFR3 / FLT-4 Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>VEGFR3/FLT-4

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>VEGFR3/FLT-4

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>VEGFR3/FLT-4

Cancer>>Growth factor & Receptor>>VEGF & Receptor>>VEGFR3/FLT-4

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>VEGFR3/FLT-4

VEGFR3 / FLT-4 Alternative Names

VEGFR3, FLT4, FLT41, LMPH1A, PCL [Homo sapiens]

VEGFR3, Flt-4, VEGFR-3, Flt4,RP23-58E13.1, AI323512, Chy [Mus musculus]

VEGFR3 / FLT-4 Background

Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Mutations in VEGFR3 have been identified in patients with primary lymphoedema. The VEGF-C/VEGF-D/VEGFR3 signaling pathway may provide a target for antilymphangiogenic therapy in prostate cancer, breast cancer, gastric cancer, lung cancer, non-small cell lung cancer (NSCLC), and so on.

VEGFR3 / FLT-4 Related Studies

1. Shushanov S, et al. (2000)VEGFc and VEGFR3 expression in human thyroid pathologies. Int J Cancer.86(1): 47-52.
2. Iljin K, et al. (2001) VEGFR3 gene structure, regulatory region, and sequence polymorphisms. FASEB J. 15(6): 1028-36.
3. Liu XE, et al. (2004) Expression and significance of VEGF-C and FLT-4 in gastric cancer. World J Gastroenterol. 10(3): 352-5.
4. Stearns ME, et al. (2004) Expression of a flt-4 (VEGFR3) splicing variant in primary human prostate tumors. VEGF D and flt-4t(Delta773-1081) overexpression is diagnostic for sentinel lymph node metastasis. Lab Invest. 84(6): 785-95.