VEGFR2 Protein (Flk-1, CD309 Protein)

Vascular Endothelial Growth Factor Receptor 2 (Fetal liver kinase 1, Cluster of Differentiation 309)

VEGFR2 Products

VEGFR2 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
VEGFR2/Flk-1/CD309	Human	VEGFR2/Flk-1/CD309/Fc Protein, Recombinant	10012-H02H
VEGFR2/Flk-1/CD309	Human	VEGFR2 / Flk-1 / CD309 Protein, Recombinant	10012-H08H
VEGFR2/Flk-1/CD309	Human	KDR / VEGFR2 / CD309 Protein, Recombinant, with GST Tag	10012-H20B1
VEGFR2/Flk-1/CD309	Mouse	KDR / VEGFR2 / CD309 Protein, Recombinant	50998-M02H
VEGFR2/Flk-1/CD309	Mouse	KDR / VEGFR2 / CD309 Protein, Recombinant	50998-M08H
VEGFR2/Flk-1/CD309	Rat	KDR / VEGFR2 / CD309 Protein, Recombinant	80113-R02H
VEGFR2/Flk-1/CD309	Rat	KDR / VEGFR2 / CD309 Protein, Recombinant	80113-R08H

10012-H02H:

1. Immobilized recombinant human VEGF / VEGFA at 1.25 μg/ml (100μl/well) can bind VEGFR2 with a linear range of 1.25-40.0 ng/ml. Measured by its binding ability in a functional ELISA.

2. The ED50 for this effect is typically 9.6 ng/mL in the presence of 5 ng/mL recombinant human VEGF165. Measured by its ability to inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells (HUVEC).

VEGFR2 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
VEGFR2/Flk-1/CD309	Human	CD309 / VEGFR2 cDNA Clone / ORF Clone	HG10012-M
VEGFR2/Flk-1/CD309	Mouse	VEGFR2/Flk-1/KDR cDNA Clone / ORF Clone	MG50998-G
VEGFR2/Flk-1/CD309	Human	Human CD309 / VEGFR2 ORF Expression Clone, untagged	HG10012-M-N
VEGFR2/Flk-1/CD309	Human	Human CD309 / VEGFR2 ORF Expression Clone, HA-tagged	HG10012-M-Y
VEGFR2/Flk-1/CD309	Human	Human CD309 / VEGFR2 ORF Expression Clone, FLAG-tagged	HG10012-M-F
VEGFR2/Flk-1/CD309	Human	Human CD309 / VEGFR2 ORF Expression Clone, Myc-tagged	HG10012-M-M

VEGFR2 Alternative Names

VEGFR2, FLK1, CD309, KDR, VEGFR [Homo sapiens]

VEGFR2, Flk-1, Flk1, VEGFR-2, sVEGFR-2, kdr, Krd-1, Ly73, 6130401C07, [Mus musculus]

VEGFR2 Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>VEGFR2/Flk-1/CD309

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>VEGFR2/Flk-1/CD309

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hematopoietic Stem Cell Marker>>VEGFR2/Flk-1/CD309

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Hemangioblast Marker>>VEGFR2/Flk-1/CD309

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>VEGFR2/Flk-1/CD309

Cancer>>Growth factor & Receptor>>VEGF & Receptor>>VEGFR2/Flk-1/CD309

Cancer>>Growth factor & Receptor>>Receptor Tyrosine Kinase>>VEGFR2/Flk-1/CD309

Immunology>>Cluster of Differentiation>>Hematopoietic Stem Cell CD Marker>>VEGFR2/Flk-1/CD309

VEGFR2 Background

VEGFR2, also called as KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the inhibition of VEGFR2 activity and its downstream signaling are important targets for the treatment of diseases involving angiogenesis. VEGFR2 transduces the major signals for angiogenesis via its strong tyrosine kinase activity. However, unlike other representative tyrosine kinase receptors, VEGFR2 does not use the Ras pathway as a major downstream signaling but rather uses the phospholipase C-protein kinase C pathway to signal mitogen-activated protein (MAP)-kinase activation and DNA synthesis. VEGFR2 is a direct and major signal transducer for pathological angiogenesis, including cancer and diabetic retinopathy, in cooperation with many other signaling partners; thus, VEGFR2 and its downstream signaling appear to be critical targets for the suppression of these diseases. VEGF and VEGFR2-mediated survival signaling is critical to endothelial cell survival, maintenance of the vasculature and alveolar structure and regeneration of lung tissue. Reduced VEGF and VEGFR2 expression in emphysematous lungs has been linked to increased endothelial cell death and vascular regression.

VEGFR2 Related Studies

Shibuya M. (2006) Vascular endothelial growth factor (VEGF)-Receptor2: its biological functions, major signaling pathway, and specific ligand VEGF-E. Endothelium. 13(2): 63-9.
Marwick JA, et al. (2010) Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs. J Inflamm (Lond). 7(1): 11.
Bruns AF, et al. (2010) Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis. Traffic. 11(1): 161-74.

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