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VEGFR2 / Flk-1 / CD309 / KDR Antibody, Rabbit MAb

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    Mouse KDR Antibody Product Information
    Immunogen:Recombinant Mouse VEGFR2 / Flk-1 / CD309 / KDR protein (Catalog#50998-M08H)
    Clone ID:093
    Ig Type:Rabbit IgG
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse VEGFR2 / Flk-1 / CD309 / KDR (rM VEGFR2 / Flk-1 / CD309 / KDR; Catalog#50998-M08H; P35918-1; Met1-Glu762).
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    Reactivity: Human  
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    Reactivity: Human  
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    10012-MM06-A-100
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    Reactivity: Human  
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      10012-MM06-200
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      Reactivity: Human  
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      10012-T26-50
      10012-T26-200
      10012-T26-100
      50 µg 
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      100 µg 
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      Reactivity: Human  
      Application: ELISA  IHC-P  
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      10012-T24-50
      10012-T24-200
      10012-T24-100
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      Reactivity: Human  
      Application: 
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      10012-MM03-F-25
      10012-MM03-F-100
      25 Test 
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      Reactivity: Human  
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        10012-RP01-400
        10012-RP01-200
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        400 µg 
        200 µg 
        100 µg 
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        Reactivity: Human  
        Application: 
        • Slide 1
        10012-MM06-P-25
        10012-MM06-P-100
        25 Test 
        100 Tests 
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        Reactivity: Human  
        Application: ELISA  
          10012-R002-50
          10012-R002-100
          50 µg 
          100 µg 
          Add to Cart
          Reactivity: Human  
          Application: 
          • Slide 1
          10012-MM03-A-25
          10012-MM03-A-100
          25 Test 
          100 Tests 
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          Reactivity: Human  
          Application: 
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          10012-R001-P-25
          10012-R001-P-100
          25 Test 
          100 Tests 
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          Reactivity: Human  
          Application: 
          • Slide 1
          10012-MM03-50
          10012-MM03-200
          10012-MM03-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          Reactivity: Human  
          Application: 
          • Slide 1
          10012-R001-F-25
          10012-R001-F-100
          25 Test 
          100 Tests 
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          Reactivity: Human  
          Application: 
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          10012-R001-A-25
          10012-R001-A-100
          25 Test 
          100 Tests 
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          Reactivity: Human  
          Application: 
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          10012-R001-50
          10012-R001-100
          50 µg 
          100 µg 
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          Reactivity: Mouse  
          Application: FCM  
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          50998-R004-P-25
          50998-R004-P-100
          25 Test 
          100 Tests 
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          Reactivity: Mouse  
          Application: ELISA  
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            50998-RP01-200
            50998-RP01-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: FCM  
            • Slide 1
            50998-R001-50
            50998-R001-100
            50 µg 
            100 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: FCM  
            • Slide 1
            50998-R004-A-25
            50998-R004-A-100
            25 Test 
            100 Tests 
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            Reactivity: Mouse  
            Application: FCM  
            • Slide 1
            50998-R004-50
            50998-R004-100
            50 µg 
            100 µg 
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            Reactivity: Mouse  
            Application: ELISA  
              50998-T16-50
              50998-T16-200
              50998-T16-100
              50 µg 
              200 µg 
              100 µg 
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              Reactivity: Mouse  
              Application: FCM  
              • Slide 1
              50998-R001-A-25
              50998-R001-A-100
              25 Test 
              100 Tests 
              Add to Cart
              Reactivity: Mouse  
              Application: ELISA  
                50998-R036-50
                50998-R036-100
                50 µg 
                100 µg 
                Add to Cart
                Reactivity: Mouse  
                Application: FCM  
                • Slide 1
                • Slide 1
                50998-R001-P-25
                50998-R001-P-100
                25 Test 
                100 Tests 
                Add to Cart
                Reactivity: Mouse  
                Application: FCM  
                • Slide 1
                • Slide 1
                50192-R201-P-25
                50192-R201-P-100
                25 Test 
                100 Tests 
                Add to Cart
                Reactivity: Rat  
                Application: ELISA  
                  80113-T16-50
                  80113-T16-200
                  80113-T16-100
                  50 µg 
                  200 µg 
                  100 µg 
                  Add to Cart
                  Reactivity: Rat  
                  Application: ELISA  
                    80113-RP01-400
                    80113-RP01-200
                    80113-RP01-100
                    400 µg 
                    200 µg 
                    100 µg 
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                    VEGFR2/KDR/Flk-1/CD309 Background

                    VEGFR2, also called as KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the inhibition of VEGFR2 activity and its downstream signaling are important targets for the treatment of diseases involving angiogenesis. VEGFR2 transduces the major signals for angiogenesis via its strong tyrosine kinase activity. However, unlike other representative tyrosine kinase receptors, VEGFR2 does not use the Ras pathway as a major downstream signaling but rather uses the phospholipase C-protein kinase C pathway to signal mitogen-activated protein (MAP)-kinase activation and DNA synthesis. VEGFR2 is a direct and major signal transducer for pathological angiogenesis, including cancer and diabetic retinopathy, in cooperation with many other signaling partners; thus, VEGFR2 and its downstream signaling appear to be critical targets for the suppression of these diseases. VEGF and VEGFR2-mediated survival signaling is critical to endothelial cell survival, maintenance of the vasculature and alveolar structure and regeneration of lung tissue. Reduced VEGF and VEGFR2 expression in emphysematous lungs has been linked to increased endothelial cell death and vascular regression.

                    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                    Mouse VEGFR2/KDR/Flk-1/CD309 References
                  • Shibuya M. (2006) Vascular endothelial growth factor (VEGF)-Receptor2: its biological functions, major signaling pathway, and specific ligand VEGF-E. Endothelium. 13(2): 63-9.
                  • Marwick JA, et al. (2010) Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs. J Inflamm (Lond). 7(1): 11.
                  • Bruns AF, et al. (2010) Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis. Traffic. 11(1): 161-74.
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                    Catalog: 50998-R093-100
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                    Datasheet & Documentation

                    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"