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>Human Cell Expressed
>Rat VEGFC / VEGF-C (aa 108-223) Protein (His Tag)
|Catalog||Size (Price)||Quantity||In Stock||Operation|
Vascular endothelial growth factor C Protein Datasheet
VEGFC / VEGF-C Protein Price Inquiry ( Available Sizes )
VEGFC / VEGF-C Protein Product Information
A DNA sequence encoding the rat VEGFC(O35757)(Ala108-Arg223) was expressed, fused with a polyhistidine tag at the C-terminus.
|Expression Host:||Human Cells|
VEGFC / VEGF-C Protein QC Testing
|Purity:||> 95 % as determined by SDS-PAGE||SDS-PAGE:
VEGFC / VEGF-C protein
|Immobilized rat VEGFC-His at 10 μg/ml (100 μl/well) can bind mouse VEGFR3-Fc (cat:50584-M02H), The EC50 of mouse VEGFR3-Fc (cat:50584-M02H) is 17.4-40.6 ng/ml.|
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Ala 108|
The recombinant rat VEGFC comprises 356 amino acids and predicts a molecular mass of 38.9 kDa. The apparent molecular mass of the recombinant protein is approximately 46-49 kDa in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
VEGFC / VEGF-C Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
VEGFC / VEGF-C Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|VEGF-C/VEGFC||Human||VEGF-C Protein, Recombinant||10542-H08H|
|VEGF-C/VEGFC||Rat||VEGFC / VEGF-C (aa 108-223) Protein, Recombinant||80103-R01H|
|VEGF-C/VEGFC||Rat||VEGFC / VEGF-C (aa 108-223) Protein, Recombinant||80103-R08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|WB, ELISA||Rabbit Polyclonal Antibody||10542-RP01|
|WB, ELISA||Rabbit Polyclonal Antibody (Antigen Affinity Purified)||10542-RP02|
VEGFC / VEGF-C Protein Description
Vascular endothelial growth factor (VEGF)-C is a member of the VEGF family, a group of polypeptide growth factors which play key roles in the physiology and pathology of many aspects of the cardiovascular system, including vasculogenesis, hematopoiesis, angiogenesis and vascular permeability. While VEGFC is homologous to other members of the VEGF/PDGF family, it contains the C-terminal propeptide which has an unusual structure with tandemly repeated cysteine-rich motifs. Upon biosynthesis, VEGFC is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF signalling in endothelial cells occurs through three tyrosine kinase receptors (VEGFRs) expressed by endothelial cells and hematopoietic precursors, and VEGF-C is a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. It is indicated that VEGFC undergoes a complex proteolytic maturation generating a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGFC may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults.
- Mandriota SJ. Et al., 1999, J Soc Biol. 193 (2): 159-63.
- Joukov V. et al., 1996, EMBO J. 15 (2): 290-98.
- Vladimir Joukov. et al., 1997, The EMBO Journal. 16 (13): 3898-911.