VEGF C Protein, Rat, Recombinant (aa 108-223, Fc Tag)

Cat: 80103-R01H

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VEGF C Protein, Rat, Recombinant (aa 108-223, Fc Tag) Product Information

Purity
> (73+25.1) % as determined by SDS-PAGE
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Activity
1. Immobilized mouse FLT4-His (Cat:50584-M08H) at 10 μg/mL (100 μL/well) can bind rat Fc-VEGFC, The EC50 of rat Fc-VEGFC is 0.41-0.95 μg/mL.
2. Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC). The ED50 for this effect is 20-100ng/mL.
Protein Construction
A DNA sequence encoding the rat VEGFC (O35757) (Ala108-Arg223) was expressed, fused with the Fc region of human IgG1 at the N-terminus.
Accession#
Expressed Host
HEK293 Cells
Species
Rat
Predicted N Terminal
Glu
Molecule Mass
The recombinant Rat VEGFC/Fc comprises 376 amino acids and has a predicted molecular mass of 41.5 kDa. The apparent molecular mass of the protein is approximately 44 and 34 kDa in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

VEGF C Protein, Rat, Recombinant (aa 108-223, Fc Tag) in SDS-PAGE

Rat VEGFC/VEGF-C/Flt4-L Protein 12385

VEGF C Background Information

Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotein, as a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. VEGF-C may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. VEGF-C protein is over-expressed in various human cancers including breast cancer and prostate cancer. VEGF-C/VEGFR-3 axis, through different signaling pathways, plays a critical role in cancer progression by regulating different cellular functions, such as invasion, proliferation, and resistance to chemotherapy. Thus, targeting the VEGF-C/VEGFR-3 axis may be therapeutically significant for certain types of tumors.

Full Name
vascular endothelial growth factor C
References
  • Joukov V, et al. (1997) Vascular endothelial growth factors VEGF-B and VEGF-C. J Cell Physiol. 173(2): 211-5.
  • Su JL, et al. (2007) The role of the VEGF-C/VEGFR-3 axis in cancer progression. Br J Cancer. 96(4): 541-5.
  • Anisimov A, et al. (2009) Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle. Circ Res. 104(11): 1302-12.
  • Other VEGF C Proteins

    Rat VEGF C Proteins

    Product Name Cat.No.
    VEGF C Protein, Rat, Recombinant (aa 108-223, His Tag) 80103-R08H

    Mouse VEGF C Proteins

    Product Name Cat.No.
    VEGF C Protein, Mouse, Recombinant (His Tag) 50391-M08H

    Human VEGF C Proteins

    Product Name Cat.No.
    VEGF C Protein, Human, Recombinant (His Tag) 10542-H08H
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