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Rat VEGFC / VEGF-C Protein (aa 108-223, Fc Tag)

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VEGF-CProtein Product Information
Synonym:VEGFC
Protein Construction:A DNA sequence encoding the rat VEGFC (O35757) (Ala108-Arg223) was expressed, fused with the Fc region of human IgG1 at the N-terminus.
Species:Rat
Expressed Host:Human Cells
Form & Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
VEGF-CProtein QC Testing
Purity:> (73+25.1) % as determined by SDS-PAGE
Bio-Activity:Immobilized mouse FLT4-His (Cat:50584-M08H) at 10 μg/ml (100 μl/well) can bind rat Fc-VEGFC, The EC50 of rat Fc-VEGFC is 0.41-0.95 μg/ml.
Endotoxin:< 1.0 EU per μg of the protein as determined by the LAL method
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Glu
Formulation:Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Molecule Mass:The recombinant Rat VEGFC/Fc comprises 376 amino acids and has a predicted molecular mass of 41.5 kDa. The apparent molecular mass of the protein is approximately 44 and 34 kDa in SDS-PAGE under reducing conditions.
VEGF-CProtein Usage Guide
Storage:Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
80103-R01H
Background

Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotein, as a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. VEGF-C may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. VEGF-C protein is over-expressed in various human cancers including breast cancer and prostate cancer. VEGF-C/VEGFR-3 axis, through different signaling pathways, plays a critical role in cancer progression by regulating different cellular functions, such as invasion, proliferation, and resistance to chemotherapy. Thus, targeting the VEGF-C/VEGFR-3 axis may be therapeutically significant for certain types of tumors.

References
  • Joukov V, et al. (1997) Vascular endothelial growth factors VEGF-B and VEGF-C. J Cell Physiol. 173(2): 211-5.
  • Su JL, et al. (2007) The role of the VEGF-C/VEGFR-3 axis in cancer progression. Br J Cancer. 96(4): 541-5.
  • Anisimov A, et al. (2009) Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle. Circ Res. 104(11): 1302-12.
  • Rat VEGFC / VEGF-C Protein (aa 108-223, Fc Tag) on other vectors Rat VEGFC / VEGF-C Protein (aa 108-223, Fc Tag) on other vectors
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    Catalog:80103-R01H-20
    List Price: $158.00  (Save $0.00)
    Price:$158.00      [How to order]
    Availabilityon Sale
    Images
    • Rat VEGFC / VEGF-C Protein (aa 108-223, Fc Tag) SDS-PAGE
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"