VEGF Protein & Antibody (VEGF-A)

Vascular Endothelial Growth Factor

VEGF Background

Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, inhibiting apoptosis and tumor growth. VEGF-A protein is also a vasodilator that increases microvascular permeability, thus it was originally referred to as vascular permeability factor.

VEGF Products

VEGF Protein, Recombinant

Molecule	Species	Description	Cat. No
VEGF/VEGF-A	Human	VEGF 121 Protein, Recombinant, with Native	10008-HNAB
VEGF/VEGF-A	Human	VEGF 165 Protein, Recombinant, Native	11066-HNAB
VEGF/VEGF-A	Human	VEGF 183 Protein, Recombinant, Native	10009-HNAB
VEGF/VEGF-A	Rat	VEGF164 / VEGFA Protein, Recombinant, Native	80006-RNAB

10008-HNAB: The ED₅₀ for this effect is typically 21.6 ng/mL.. Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC).

11066-HNAB: ED₅₀ = 3-5 ng/ml. Measured in a cell proliferation assay using human umbilical vein endothelial cells  (HUVEC).

VEGF Antibody

Molecule	Application	Description	Cat. No
Human VEGF/VEGF-A	WB, ELISA	VEGF/VEGF-A Antibody, Rabbit PAb	11066-RP01
Human VEGF/VEGF-A	WB, ELISA	VEGF/VEGF-A Antibody, Rabbit PAb (Antigen Affinity Purified)	11066-RP02
Human VEGF/VEGF-A	WB, ELISA	VEGF121 / VEGF-A Antibody	10008-RP01
Human VEGF/VEGF-A	WB, ELISA	VEGF121 / VEGF-A Antibody (Antigen Affinity Purified)	10008-RP02
Human VEGF/VEGF-A	WB, ELISA	VEGF 183 / VEGF-A Antibody (Antigen Affinity Purified)	10009-RP02
Human VEGF/VEGF-A	WB, ELISA	VEGF121 / VEGF-A Antibody	10008-RP01
Human VEGF/VEGF-A	WB, ELISA	VEGF121 / VEGF-A Antibody (Antigen Affinity Purified)	10008-RP02

VEGF cDNA Clone

Molecule	Species	Description	Cat. No
VEGF/VEGF-A	Human	Homo sapiens VEGF/VEGF-A transcript variant 6 cDNA Clone(NM_001025370.1)	HG10008-M
VEGF/VEGF-A	Human	Homo sapiens VEGF/VEGF-A transcript variant 3 cDNA Clone(NM_001025367.1)	HG10009-M
VEGF/VEGF-A	Human	Homo sapiens VEGF/VEGF-A transcript variant 2 cDNA Clone(NM_003376.4)	HG10010-M
VEGF/VEGF-A	Human	VEGFA transcript variant 4 cDNA Clone / ORF Clone	HG11066-G
VEGF/VEGF-A	Mouse	Mus musculus VEGF/VEGF-A cDNA Clone	MG50159-M
VEGF/VEGF-A	Canine	Canis lupus familiars VEGF/VEGF-A cDNA Clone	CG70004-G

VEGF Related Areas

Cancer>>Cancer Biomarkers>>VEGF

Cancer >>Growth factor & Receptor>>VEGF & Receptor>>VEGF

VEGF Alternative Names

VEGF, VEGF-A, RP1-261G23.1, MGC70609, MVCD1, VPF

VEGF Protein Related Products

Protein Products

Molecule	Species	Description
Neuropilin-1	Human	Neuropilin-1/NRP1/Fc Protein, Recombinant
VEGF-C	Human	VEGF-C Protein, Recombinant
VEGF-D	Human	VEGF-D Protein, Recombinant
VEGFR1/FLT-1	Human	VEGFR1/FLT-1 Protein, Recombinant
VEGFR3/FLT-4	Human	VEGFR3/FLT-4/Fc Protein, Recombinant
VEGFR3/FLT-4	Human	VEGFR3/FLT-4 Protein, Recombinant
VEGFR3/FLT-4	Mouse	VEGFR3/FLT-4/Fc Protein, Recombinant
VEGFR3/FLT-4	Mouse	VEGFR3/FLT-4 Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human VEGF-C/VEGFC	WB, ELISA	Rabbit Polyclonal Antibody
Human VEGF-C/VEGFC	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human VEGF-D	ELISA	Rabbit Monoclonal Antibody
Human VEGF-D	WB, ELISA	FIGF/VEGF-D Antibody, Rabbit MAb
Human VEGF-D	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human VEGF-D	WB, ELISA	Rabbit Polyclonal Antibody
Human VEGFR3/FLT-4	WB	Mouse Monoclonal Antibody
Human VEGFR3/FLT-4	ELISA	Mouse Monoclonal Antibody
Human VEGFR3/FLT-4	ELISA	Rabbit Polyclonal Antibody
Human VEGFR3/FLT-4	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
Neuropilin-1	Human	Homo sapiens Neuropilin-1 transcript variant 2 cDNA Clone(NM_001024628.2)
VEGF-B	Human	Homo sapiens VEGF-B cDNA Clone(NM_003377.3)
VEGF-B	Mouse	Mus musculus VEGF-B cDNA Clone
VEGF-C	Human	Homo sapiens VEGF-C cDNA Clone(NM_005429.2)
VEGF-C	Mouse	Mus musculus VEGF-C cDNA Clone
FIGF/VEGF-D	Human	Homo sapiens FIGF/VEGF-D cDNA Clone
FIGF/VEGF-D	Mosue	Mus musculus FIGF/VEGF-D cDNA Clone
VEGFR1/FLT-1	Human	Human VEGFR1/FLT-1 cDNA Clone / ORF Clone
VEGFR3/FLT-4	Human	Homo sapiens VEGFR3/FLT-4 cDNA Clone

VEGF Related Studies

1. Woolard J. et al. (2004) VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression. Cancer Res. 64(21): 7822-7835.
2. Jia SF, et al. (2008) VEGF165 is necessary to the metastatic potential of Fas(-) osteosarcoma cells but will not rescue the Fas(+) cells. J Exp Ther Oncol. 7(2): 89-97.
3. Cimpean AM, et al. (2008) Vascular endothelial growth factor A (VEGF A) as individual prognostic factor in invasive breast carcinoma. Rom J Morphol Embryol. 49(3): 303-8.
4. Hamdollah Zadeh MA, et al. (2008) VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6. Microcirculation. 15(7): 605-14.
5. Eisenach PA, et al. (2010) MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src. J Cell Sci. 123(Pt 23):4182-4193.
6. Claesson-Welsh L (2010) Gremlin: vexing VEGF receptor agonist. Blood. 116(18):3386-7.