VEGFD Protein, Mouse, Recombinant (His Tag)

Cat: 50157-M08H
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VEGFD Protein, Mouse, Recombinant (His Tag) Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Activity
Measured by its ability to bind with mouse FLT4-Fc (Cat:50584-M02H) in a functional ELISA.
Protein Construction
A DNA sequence encoding the mouse FIGF (P97946) (Phe98-Ser206) was expressed with a C-terminal polyhistidine tag.
Reference#
Expressed Host
HEK293 Cells
Species
Mouse
Predicted N Terminal
Phe 98
Molecule Mass
The recombinant mouse FIGF comprises 120 amino acids and has a predicted molecular mass of 14 kDa. The apparent molecular mass of the protein is approximately 22 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation
Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
VEGFD Protein, Mouse, Recombinant (His Tag) in SDS-PAGE
Mouse FIGF/VEGF-D Protein 11442
VEGFD Protein, Mouse, Recombinant (His Tag) Alternative Names
AI325264 Protein, Mouse;VEGF-D Protein, Mouse;Vegfd Protein, Mouse
VEGFD Background Information

Vascular endothelial growth factor D (VEGF-D), also known as C-fos induced growth factor (FIGF), belongs to the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. FIGF protein is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. FIGF protein is secreted as a non-covelent homodimer in an antiparallel fashion. Human FIGF protein is expressed in adult lung, heart, muscle, and small intestine, and is most abundantly expressed in fetal lungs and skin. FIGF protein is structurally and functionally similar to VEGF-C. Therefore, FIGF protein binds and activates VEGFR-2 (Flk1) and VEGFR-3 (Flt4) receptors, and may particularly be involved in cancers, such as breast cancer, epithelial ovarian carcinoma and so on.

Full Name
c-fos induced growth factor (vascular endothelial growth factor D)
References
  • Avantaggiato V, et al. (1998) Embryonic expression pattern of the murine figf gene, a growth factor belonging to platelet-derived growth factor/vascular endothelial growth factor family. Mech Dev. 73(2):221-4.
  • Rocchigiani M, et al. (1998) Human FIGF: cloning, gene structure, and mapping to chromosome Xp22.1 between the PIGA and the GRPR genes. Genomics 47(2):207-16.
  • Karpanen T, et al. (2008) VEGF-D: a modifier of embryonic lymphangiogenesis. Blood. 112(5): 1547-8.
  • Other VEGFD Proteins

    Rat VEGFD Proteins

    Product Name Cat.No.
    VEGFD Protein, Rat, Recombinant (Fc Tag) 80104-R01H

    Mouse VEGFD Proteins

    Product Name Cat.No.
    VEGFD Protein, Mouse, Recombinant (Fc Tag) 50157-M01H

    Human VEGFD Proteins

    Product Name Cat.No.
    VEGFD Protein, Human, Recombinant (His Tag) 10557-H08H
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