All VEGF C reagents are produced in house and quality controlled, including 3 VEGF C Antibody, 36 VEGF C Gene, 4 VEGF C Lysate, 4 VEGF C Protein, 3 VEGF C qPCR. All VEGF C reagents are ready to use.
Recombinant VEGF C proteins are expressed by HEK293 Cells with fusion tags as N-human IgG1-Fc, C-His.
VEGF Cantibodies are validated with different applications, which are ELISA.
VEGF CcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each VEGF C of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotein, as a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. VEGF-C may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. VEGF-C protein is over-expressed in various human cancers including breast cancer and prostate cancer. VEGF-C/VEGFR-3 axis, through different signaling pathways, plays a critical role in cancer progression by regulating different cellular functions, such as invasion, proliferation, and resistance to chemotherapy. Thus, targeting the VEGF-C/VEGFR-3 axis may be therapeutically significant for certain types of tumors.