VEGF-C Protein & Antibody (VEGFC)

Vascular Endothelial Growth Factor C

VEGF-C Products

VEGF-C Protein, Recombinant

Molecule	Species	Description	Cat. No
VEGF-C/VEGFC	Human	VEGF-C Protein, Recombinant	10542-H08H

  10542-H08H: Scatchard analysis showed the affinity constant (Kd) of recombinant human VEGF-C bound to recombinant human VEGFR3 was 1.4 nM. Measured by its binding ability in a functional ELISA.

VEGF-C Antibody

Molecule	Application	Description	Cat. No
Human VEGF-C/VEGFC	WB, ELISA	Rabbit Polyclonal Antibody	10542-RP01
Human VEGF-C/VEGFC	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10542-RP02

VEGF-C cDNA Clone

Molecule	Species	Description	Cat. No
VEGF-C/VEGFC	Human	Homo sapiens VEGF-C cDNA Clone(NM_005429.2)	HG10542-M
VEGF-C/VEGFC	Mouse	Mus musculus VEGF-C cDNA Clone	MG50391-M

VEGF-C Alternative Names

VEGF-C, VEGFC, Flt4-L, VRP

VEGF-C Related Areas

Cancer >>Growth factor & Receptor>>VEGF & Receptor>>VEGF-C

VEGF-C Protein Related Products

Protein Products

Molecule	Species	Description
Neuropilin-1	Human	Neuropilin-1/NRP1/Fc Protein, Recombinant
PDGF-C	Human	PDGF-C/Fc Protein, Recombinant
PDGF-D	Human	PDGF-D/Fc Protein, Recombinant
PDGFRA/CD140a	Human	PDGFRA/CD140a/Fc Protein, Recombinant
PDGFRA/CD140a	Human	PDGFRA/CD140a Protein, Recombinant
PDGFRA/CD140a	Human	PDGFRA/CD140a Protein, Recombinant
VEGF/VEGF-A	Human	VEGF 121 Protein, Recombinant
VEGF/VEGF-A	Human	VEGF 165 Protein, Recombinant
VEGF/VEGF-A	Human	VEGF 183 Protein, Recombinant
VEGF-D	Human	VEGF-D Protein, Recombinant
VEGFR1/FLT-1	Human	VEGFR1/FLT-1 Protein, Recombinant
VEGFR3/FLT-4	Human	VEGFR3/FLT-4/Fc Protein, Recombinant
VEGFR3/FLT-4	Human	VEGFR3/FLT-4 Protein, Recombinant
VEGFR3/FLT-4	Mouse	VEGFR3/FLT-4/Fc Protein, Recombinant
VEGFR3/FLT-4	Mouse	VEGFR3/FLT-4 Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human PDGFRA/CD140a	ELISA	Mouse Monoclonal Antibody
Human PDGFRA/CD140a	WB, ELISA	Rabbit Monoclonal Antibody
Human PDGFRA/CD140a	WB, ELISA	Rabbit Polyclonal Antibody
Human PDGFRA/CD140a	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human VEGF/VEGF-A	WB, ELISA	VEGF/VEGF-A Antibody, Rabbit PAb
Human VEGF/VEGF-A	WB, ELISA	VEGF/VEGF-A Antibody, Rabbit PAb (Antigen Affinity Purified)
Human VEGF-D	ELISA	Rabbit Monoclonal Antibody
Human VEGF-D	WB, ELISA	FIGF/VEGF-D Antibody, Rabbit MAb
Human VEGF-D	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human VEGF-D	WB, ELISA	Rabbit Polyclonal Antibody
Human VEGFR3/FLT-4	WB	Mouse Monoclonal Antibody
Human VEGFR3/FLT-4	ELISA	Mouse Monoclonal Antibody
Human VEGFR3/FLT-4	ELISA	Rabbit Polyclonal Antibody
Human VEGFR3/FLT-4	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
Neuropilin-1	Human	Homo sapiens Neuropilin-1 transcript variant 2 cDNA Clone(NM_001024628.2)
PDGF-B	Human	Homo sapiens PDGF-B cDNA Clone(NM_002608.2)
PDGF-C	Human	Homo sapiens PDGF-C cDNA Clone(NM_016205.1)
PDGF-D	Human	Homo sapiens PDGF-D transcript variant 1 cDNA Clone(NM_025208.4)
PDGFRA/CD140a	Human	Homo sapiens PDGFRA/CD140a cDNA Clone(NM_006206.4)
PGF/PLGF	Human	Homo sapiens PGF/PLGF cDNA Clone(NM_002632.4)
VEGF/VEGF-A	Human	Homo sapiens VEGF/VEGF-A transcript variant 6 cDNA Clone(NM_001025370.1)
VEGF/VEGF-A	Human	Homo sapiens VEGF/VEGF-A transcript variant 3 cDNA Clone(NM_001025367.1)
VEGF/VEGF-A	Human	Homo sapiens VEGF/VEGF-A transcript variant 2 cDNA Clone(NM_003376.4)
VEGF/VEGF-A	Mouse	Mus musculus VEGF/VEGF-A cDNA Clone
VEGF/VEGF-A	Canine	Canis lupus familiars VEGF/VEGF-A cDNA Clone
VEGF-B	Human	Homo sapiens VEGF-B cDNA Clone(NM_003377.3)
VEGF-B	Mouse	Mus musculus VEGF-B cDNA Clone
FIGF/VEGF-D	Human	Homo sapiens FIGF/VEGF-D cDNA Clone
FIGF/VEGF-D	Mosue	Mus musculus FIGF/VEGF-D cDNA Clone
VEGFR1/FLT-1	Human	Human VEGFR1/FLT-1 cDNA Clone / ORF Clone
VEGFR3/FLT-4	Human	Homo sapiens VEGFR3/FLT-4 cDNA Clone

VEGF-C Background

Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotein, as a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. VEGF-C may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. VEGF-C protein is over-expressed in various human cancers including breast cancer and prostate cancer. VEGF-C/VEGFR-3 axis, through different signaling pathways, plays a critical role in cancer progression by regulating different cellular functions, such as invasion, proliferation, and resistance to chemotherapy. Thus, targeting the VEGF-C/VEGFR-3 axis may be therapeutically significant for certain types of tumors.

VEGF-C Related Studies

1. Joukov V, et al. (1997) Vascular endothelial growth factors VEGF-B and VEGF-C. J Cell Physiol. 173(2): 211-5.
2. Su JL, et al. (2007) The role of the VEGF-C/VEGFR-3 axis in cancer progression. Br J Cancer. 96(4): 541-5.
3. Anisimov A, et al. (2009) Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle. Circ Res. 104(11): 1302-12.