All VE-Cadherin reagents are produced in house and quality controlled, including 26 VE-Cadherin Antibody, 1 VE-Cadherin ELISA, 39 VE-Cadherin Gene, 4 VE-Cadherin Lysate, 4 VE-Cadherin Protein, 3 VE-Cadherin qPCR. All VE-Cadherin reagents are ready to use.
Recombinant VE-Cadherin proteins are expressed by HEK293 Cells with fusion tags as C-His, C-human IgG1-Fc & His, C-human IgG1-Fc.
VE-Cadherinantibodies are validated with different applications, which are IHC-P, WB, ELISA, FCM, ELISA(Cap), ELISA(Det).
VE-CadherincDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each VE-Cadherin of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
VE-CadherinELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.