VE-Cadherin / CD144 Protein & Antibody (CDH5)

VE-Cadherin / CD144 Products

VE-Cadherin / CD144 Protein, Recombinant

Molecule	Species	Description	Cat. No
VE-Cadherin/CD144/CDH5	Human	VE-Cadherin/CD114/Fc Protein, Recombinant	10433-H03H
VE-Cadherin/CD144/CDH5	Mouse	VE-Cadherin/CD114 Protein, Recombinant	50192-M08H

VE-Cadherin / CD144 Antibody

Molecule	Application	Description	Cat. No
Mouse VE-Cadherin /CD144/CDH5	WB, ELISA	Rabbit Polyclonal Antibody	50192-RP01
Mouse VE-Cadherin /CD144/CDH5	WB, ELISA	VE-Cadherin / CD144 / CDH5 Antibody (Antigen Affinity Purified)	50192-RP02

VE-Cadherin / CD144 cDNA Clone

Molecule	Species	Description	Cat. No
VE-Cadherin/CD144/CDH5	Human	Homo sapiens VE-Cadherin/CD114/CDH5 cDNA Clone(NM_001795.3)	HG10433-M
VE-Cadherin/CD144/CDH5	Mouse	Mus musculus VE-Cadherin/CD114/CDH5 cDNA Clone	MG50192-M

VE-Cadherin / CD144 Alternative Names

VE-Cadherin, CD144, CDH5, 7B4, FLJ17376 [Homo sapiens]

VE-Cadherin, Cd144, Cdh5, VE-Cad, VECD, Vec, 7B4, AA408225 [Mus musculus]

VE-Cadherin / CD144 Related Areas

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Hemangioblast Marker>>VE-Cadherin/CD144

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>VE-Cadherin/CD144

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>VE-Cadherin/CD144

Immunology>>Adhesion Molecule>> Cadherin>> VE-Cadherin/CD144/CDH5

Immunology>>Cluster of Differentiation>>Other>>VE-Cadherin/CD144

VE-Cadherin / CD144 Related Products

Protein Products

Molecule	Species	Description
E-Cadherin/CDH1/CD324	Human	E-Cadherin/CDH1 Protein, Recombinant
E-Cadherin/CDH1	Mouse	E-Cadherin/CDH1 Protein, Recombinant
N-Cadherin/CD325/CDH2	Human	N-Cadherin/CD325/CDH2 Protein, Recombinant
R-Cadherin/CDH4	Mouse	R-Cadherin/CDH4 Protein, Recombinant
Cadherin-6/K-Cadherin/CDH6	Human	Cadherin-6/K-Cadherin/CDH6 Protein, Recombinant
Cadherin-8/CDH8	Human	Cadherin-8/CDH8 Protein, Recombinant
Cadherin-12/CDH12	Human	Cadherin-12/CDH12 Protein, Recombinant
KSP-Cadherin/Cadherin-16/CDH16	Human	KSP-Cadherin/Cadherin-16/CDH16 Protein, Recombinant
Cadherin-17/LI-cadherin	Human	Cadherin-17/LI-cadherin Protein, Recombinant

Antibody Products

Molecule	Applications	Description
Human E-Cadherin/CDH1/CD324	WB, ELISA	Mouse Monoclonal Antibody
Human E-Cadherin/CDH1/CD324	ELISA	Mouse Monoclonal Antibody
Human E-Cadherin/CDH1/CD324	WB, ELISA	Rabbit Polyclonal Antibody
Human E-Cadherin/CDH1/CD324	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human R-Cadherin/CDH4	WB, ELISA	R-Cadherin/CDH4 Antibody, Rabbit PAb
Human R-Cadherin/CDH4	WB, ELISA	R-Cadherin/CDH4 Antibody, Rabbit PAb (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
E-Cadherin/CDH1/CD324	Human	Homo sapiens E-Cadherin/CDH1 cDNA Clone(NM_004360.3)
N-Cadherin/CD325/CDH2	Human	Homo sapiens N-Cadherin/CD325/CDH2 cDNA Clone(NM_001792.3)
P-Cadherin/CDH3	Human	Homo sapiens P-Cadherin/CDH3 cDNA Clone(NM_001793.4)
Cadherin-6/K-Cadherin/CDH6	Human	Homo sapiens Cadherin-6/K-Cadherin/CDH6 cDNA Clone(NM_004932.2)
Cadherin-8/CDH8	Human	Homo sapiens Cadherin-8/CDH8 cDNA Clone(NM_001796.2)
Cadherin-11/CDH11	Human	Homo sapiens Cadherin-11/CDH11 cDNA Clone(NM_001797.2)
Cadherin-12/CDH12	Human	Homo sapiens Cadherin-12/CDH12 cDNA Clone(NM_004061.3)
KSP-Cadherin/CDH16	Human	Homo sapiens Cadherin-16/CDH16 cDNA Clone(NM_004062.2)
Cadherin-17/LI-cadherin	Human	Homo sapiens Cadherin-17/LI-cadherin/CDH17 cDNA Clone

VE-Cadherin / CD144 Background

Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.

VE-Cadherin / CD144 Related Studies

1. Taveau JC, et al. (2008) Structure of artificial and natural VE-cadherin-based adherens junctions. Biochem Soc Trans. 36(Pt 2): 189-93.
2. Vestweber D. (2008) VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler Thromb Vasc Biol. 28(2): 223-32.
3. Gavard J. (2009) Breaking the VE-cadherin bonds. FEBS Lett. 583(1): 1-6.
4. Vestweber D, et al. (2009) Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player. Trends Cell Biol. 19(1): 8-15.
5. Boda-Heggemann J, et al. (2009) Beyond vessels: occurrence and regional clustering of vascular endothelial (VE-)cadherin-containing junctions in non-endothelial cells. Cell Tissue Res. 335(1): 49-65.