Anti-VE-Cadherin Antibody

Cat: 50192-RP01
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Anti-VE-Cadherin Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-VE-Cadherin Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse VE-Cadherin
Immunogen
Recombinant Mouse CDH5 protein (Catalog#50192-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse CDH5 extracellular domain (rM CDH5; Catalog#50192-M08H; NP_033998.2; Met 1-Ala 592). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-VE-Cadherin Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-VE-Cadherin Antibody Alternative Names
Anti-7B4 Antibody;Anti-AA408225 Antibody;Anti-Cd144 Antibody;Anti-VE-Cad Antibody;Anti-Vec Antibody;Anti-VEcad Antibody;Anti-VECD Antibody
VE-Cadherin Background Information

Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.

Full Name
cadherin 5, type 2 (vascular endothelium)
References
  • Taveau JC, et al. (2008) Structure of artificial and natural VE-cadherin-based adherens junctions. Biochem Soc Trans. 36(Pt 2): 189-93.
  • Vestweber D. (2008) VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler Thromb Vasc Biol. 28(2): 223-32.
  • Gavard J. (2009) Breaking the VE-cadherin bonds. FEBS Lett. 583(1): 1-6.
  • Vestweber D, et al. (2009) Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player. Trends Cell Biol. 19(1): 8-15.
  • Boda-Heggemann J, et al. (2009) Beyond vessels: occurrence and regional clustering of vascular endothelial (VE-)cadherin-containing junctions in non-endothelial cells. Cell Tissue Res. 335(1): 49-65.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-VE-Cadherin Antibody Rabbit Polyclonal ELISA 80276-RP01
    Anti-VE-Cadherin Antibody Rabbit Polyclonal ELISA 80276-T16
    Anti-VE-Cadherin Antibody Mouse Monoclonal WB 80276-MM05
    Anti-VE-Cadherin Antibody Mouse Monoclonal ELISA 80276-MM06
    Anti-VE-Cadherin Antibody Rabbit Monoclonal WB,ELISA 50192-R311
    Anti-VE-Cadherin Antibody Rabbit Monoclonal ELISA 50192-R228
    Anti-VE-Cadherin Antibody Rabbit Polyclonal ELISA 50192-RP02
    Anti-VE-Cadherin Antibody (APC) Rabbit Monoclonal FCM 50192-R201-A
    Anti-VE-Cadherin Antibody (PE) Rabbit Monoclonal FCM 50192-R201-P
    Anti-VE-Cadherin Antibody Rabbit Polyclonal WB,ELISA,IHC-P 50192-T56
    Anti-VE-Cadherin Antibody Rabbit Monoclonal FCM 50192-R201
    Anti-VE-Cadherin Antibody Rabbit Polyclonal ELISA 10433-RP01
    Anti-VE-Cadherin Antibody Rabbit Monoclonal ELISA,ELISA(Det),FCM 10433-R048
    Anti-VE-Cadherin Antibody Mouse Monoclonal ELISA(Cap) 10433-MM04
    Anti-VE-Cadherin Antibody (FITC) Rabbit Monoclonal FCM 10433-R048-F
    Anti-VE-Cadherin Antibody (APC) Rabbit Monoclonal FCM 10433-R048-A
    Anti-VE-Cadherin Antibody Rabbit Polyclonal ELISA 10433-T16
    Anti-VE-Cadherin Antibody (FITC) Mouse Monoclonal FCM 10433-MM01-F
    Anti-VE-Cadherin Antibody (PE) Mouse Monoclonal FCM 10433-MM01-P
    Anti-VE-Cadherin Antibody Mouse Monoclonal ELISA 10433-MM02
    Anti-VE-Cadherin Antibody (PE) Rabbit Monoclonal FCM 10433-R048-P
    Anti-VE-Cadherin Antibody (APC) Mouse Monoclonal FCM 10433-MM01-A
    Anti-VE-Cadherin Antibody Rabbit Monoclonal IHC-P 10433-R012
    Anti-VE-Cadherin Antibody Mouse Monoclonal FCM 10433-MM01
    Anti-VE-Cadherin Antibody Rabbit Polyclonal WB 100305-T32
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