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VCL / Vinculin Protein

Vinculin

VCL Products

VCL Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
VCL Human VCL / Vinculin Protein, Recombinant 10019-H08H

VCL cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
VCL Human Vinculin transcript variant 2 cDNA Clone / ORF Clone HG10019-M
VCL Mouse VCL cDNA Clone / ORF Clone MG50773-G

VCL Related Areas

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>VCL

VCL Alternative Names

RP11-178G16.3, CMD1W, CMH15, MVCL[Homo sapiens]

9430097D22, AA571387, AI462105, AW545629[Mus musculus]

VCL Background

Vinculin (VCL) is a cytoskeletal protein that is closely related to both cell-matrix interactions and cell-cell junctions. VCL is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. The protein contains an acidic N-terminal domain and a basic C-terminal domain separated by a proline-rich middle segment. This protein has multi-ligand properties and has been found to interact with a number of microfilament associated proteins, such as talin, a-actinin, and paxillin, which reportedly bind to either the head or tail domains of vinculin.

VCL Related Studies

  1. Massoumi R, et al. (2001) Leukotriene D(4) affects localisation of vinculin in intestinal epithelial cells via distinct tyrosine kinase and protein kinase C controlled events. J Cell Sci. 114(10): 1925-34.
  2. Turner CE, et al. (1994) Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak-binding region. J Cell Sci. 107 (6): 1583-91.
  3. Strasser P, et al. (1993) Variable and constant regions in the C-terminus of vinculin and metavinculin: cloning and expression of fragments in E. coli. FEBS Lett. 317: 189-194.

 

VCL/Vinculin related areas, pathways, and other information

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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