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VCAM-1/CD106 Protein, Antibody, ELISA Kit, cDNA Clone

Mouse VCAM-1/CD106 Protein

Description: Active
Expression host: Human Cells
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50163-M03H-100
50163-M03H-200
100 µg / $198
200 µg / $298
Add to Cart
Description: Active
Expression host: Human Cells
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50163-M08H-100
50163-M08H-200
100 µg / $198
200 µg / $298
Add to Cart

Human VCAM-1/CD106 Protein

Description: Active
Expression host: Human Cells
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10113-H02H-100
10113-H02H-200
100 µg / $198
200 µg / $298
Add to Cart
Description: Active
Expression host: Human Cells
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10113-H07H-100
10113-H07H-200
100 µg / $178
200 µg / $298
Add to Cart
Description: Active
Expression host: Human Cells
  • Slide 1
10113-H08H-100
10113-H08H-200
100 µg / $178
200 µg / $298
Add to Cart

VCAM-1/CD106 Related Areas

VCAM-1/CD106 Related Pathways

VCAM-1/CD106 Related Product

    VCAM-1/CD106 Summary & Protein Information

    VCAM-1/CD106 Background

    Gene Summary: This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene.
    General information above from NCBI
    Subunit structure: Binds to ECMV-D capsid proteins and acts as a receptor for this virus (By similarity).
    Domain: Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
    Subcellular location: Membrane; Single-pass type I membrane protein.
    Tissue specificity: Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
    Induction: By cytokines (e.g. IL-1, TNF-alpha).
    Post-translational: Sialoglycoprotein.
    Sequence similarity: Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
    General information above from UniProt

    Vascular cell adhesion molecule 1 (VCAM-1), also known as CD106, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM-1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant. VCAM-1 is an endothelial ligand for very late antigen-4 (VLA-4) and α4ß7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.

    VCAM-1/CD106 Alternative Name

    CD106,DKFZp779G2333,INCAM-100,MGC99561,VCAM1,VCAM-1, [human]
    CD106,VCAM1,VCAM-1, [mouse]

    VCAM-1/CD106 Related Studies

  • Cook-Mills JM. (2002) VCAM-1 signals during lymphocyte migration: role of reactive oxygen species. Mol Immunol. 39(9): 499-508.
  • Preiss DJ, et al. (2007) Vascular cell adhesion molecule-1: a viable therapeutic target for atherosclerosis? Int J Clin Pract. 61(4): 697-701.
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