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VCAM-1 / CD106 Antibody Datasheet
|Order or Inquire for VCAM-1 / CD106 Antibody product||Quality antibodies||Antibody production services|
|Detection limit is 0.00245 ng/well in ELISA|
VCAM-1 / CD106 Antibody Product Information
Recombinant Mouse VCAM-1 / CD106 protein (Catalog#50163-M08H)
|Antibody Type :||Rabbit Polyclonal Antibody ( Antibody Purification Platform )|
|Ig Type :||
|Formulation :||0.2 μm filtered solution in PBS with 5% trehalose|
Produced in rabbits immunized with purified, recombinant Mouse VCAM-1 / CD106 (rM VCAM-1 / CD106; Catalog#50163-M08H; NP_035823.3; Met 1-Glu 698). Total IgG was purified by Protein A affinity chromatography.
VCAM-1 / CD106 Antibody Usage Guide
Mouse VCAM-1 / CD106
|Western blot :||This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse VCAM1 in WB.|
|Direct ELISA :||This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Mouse VCAM1. The detection limit for Mouse VCAM1 is approximately 0.00245 ng/well.|
|Storage :||This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
VCAM-1 / CD106 Antibody Related Products & Topics
VCAM-1 / CD106 Antibody Background
Vascular cell adhesion molecule 1 (VCAM1), also known as CD106, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant. VCAM1 is expressed by a variety of cell types including activated endothelial cells, macrophages, dendritic cells, neurons, smooth muscle cells, fibroblasts, and oocytes. Up-regulation of VCAM1 in endothelial cells is induced by the cytokines IL-1β, IL-4, TNF-α and IFN-γ. VCAM1 is an endothelial ligand for very late antigen-4 (VLA-4) and α4β7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. Accordingly, VCAM1 is thought to be involved in the extravasation or emigration of leukocytes in pathological immune responses and inflammation, and may plays a role in the development of atherosclerosis and rheumatoid arthritis.
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