Uteroglobin (SCGB1A1)

Uteroglobin (UG), also known as Secretoglobin 1A member 1 (SCGB1A1), Blastokinin, Clara cell secretor protein (CCSP) or Clara cell-specific 10-kDa protein (CC10), is the founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals. This protein is mainly expressed in lung, with anti-inflammatory/immunomodulatory properties. Previous in vitro studies demonstrated that CCAAT/enhancer-binding proteins (C/EBPs) are the major transcription factors for the regulation of SCGB1A1 gene expression, whereas FOXA1 had a minimum effect on the transcription. Uteroglobin is a multifunctional protein with antiinflammatory/immunomodulatory properties. Uteroglobin inhibits soluble phospholipase A(2) activity and binds and perhaps sequesters hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids, and prostaglandins. In addition to its antiinflammatory activities, Uteroglobin manifests antichemotactic, antiallergic, antitumorigenic, and embryonic growth-stimulatory activities. The tissue-specific expression of the Uteroglobin gene is regulated by several steroid hormones, although a nonsteroid hormone, prolactin, further augments its expression in the uterus. Based on its anti-inflammatory and antiallergic properties, Uteroglobin is a potential drug target. The mechanism of Uteroglobin action is likely to be even more complex as it also functions via a putative receptor-mediated pathway.

Uteroglobin (SCGB1A1) Alternative Names

Uteroglobin, SCGB1A1, CC10, CC16, CCPBP, CCSP, UGB, UP-1, UP1 [Homo sapiens]

Uteroglobin, Scgb1a1, CC10, CC16, CCSP, PCB-BP, UG, UGB, Utg [Mus musculus]

Summaries for Uteroglobin (SCGB1A1)

Entrez Gene summary for Uteroglobin (SCGB1A1):

SCGB1A1 gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]

OMIM - description for Uteroglobin (SCGB1A1):

SCGB1A1, or uteroglobin, is an evolutionarily conserved, steroid-inducible, secreted protein. It has antiinflammatory and immunomodulatory properties and also manifests antichemotactic, antiallergic, antitumorigenic, and embryonic growth-stimulatory activities. Mucosal epithelia of virtually all organs that communicate with the external environment express uteroglobin, and it is present in blood, urine, and other body fluids (review by Mukherjee et al., 2007).

Wikipedia summary for Uteroglobin (SCGB1A1):

Uteroglobin also known as secretoglobin family 1A member 1 (SCGB1A1) is a protein that in humans is encoded by the SCGB1A1 gene.
SCGB1A1 is the founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals. This antiparallel disulfide linked homodimeric protein is multifunctional and found in various tissues in various names such as: Uteroglobin (UG, UGB), Uteroglobin-like Antigen (UGL), Blastokinin, Clara cell secretory protein (CCSP), Clara cell 16 kD protein (17 in rat/mice), Clara Cell-Specific 10 kD Protein (CC10), human protein 1, urine protein 1 (UP-1), polychlorinated biphenyl-binding protein (PCB-BP), human Clara Cell Phospholipid-Binding Protein (hCCPBP), Secretoglobin 1A member 1 (SCGB1A1).
This protein is specifically expressed in Clara cells in the lungs.

Human Uteroglobin (SCGB1A1) Protein General Information

 

• Protein names: Uteroglobin
• Sequence length: 91 AA.
• Domain: Signal
• Sequence similarities: Belongs to the secretoglobin family.
• Subunit structure: Homodimer; antiparallel disulfide-linked.
• Subcellular location: Secreted.
• Tissue specificity: Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).

General information above from UniProt

Function for Uteroglobin (SCGB1A1) Protein

UniProtKB:

Uteroglobin binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

Genatlas:

• Uteroglobin is involved in embryo implantation
• Uteroglobin acts as an inhibitor of phospholipase A2

Homology for human Uteroglobin (SCGB1A1)

• homolog to rattus Scgb1a1 (55.56 pc)
• homolog to murine Scgb1a1 (55.56 pc)

Phenotype Information for Uteroglobin (SCGB1A1)

• Gene/Locus: SCGB1A1, UGB, CC10, CCSP, SCGB1A1
• Phenotype: {Asthma, susceptibility to}

Phenotype Information for Uteroglobin (SCGB1A1) from OMIM (Online Mendelian Inheritance in Man)