Uteroglobin / SCGB1A1 Protein & Antibody

Secretoglobin, family 1A, member 1

Uteroglobin / SCGB1A1 Products

Uteroglobin / SCGB1A1 Protein, Recombinant

Molecule	Species	Description	Cat. No
Uteroglobin/SCGB1A1	Human	Uteroglobin/SCGB1A1 Protein, Recombinant	10808-H08H
Uteroglobin/SCGB1A1	Mouse	Uteroglobin/SCGB1A1 Protein, Recombinant	50291-M08H

  10808-H08H: When 5 x 10⁴ cells/well are added to human SCGB1A1 coated plates (2 µg/mL and 100 µl/well), approximately > 50% will adhere after one hour at 37 ℃. Measured by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cell line.

  50291-M08H: When 5 x 10⁴ cells/well are added to SCGB1A1 coated plates (5 µg/mL with 100 µL/well), approximately >40% will adhere after 1 hour at 37℃.Measured by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cell line.

Uteroglobin / SCGB1A1 Antibody

Molecule	Application	Description	Cat. No
Human Uteroglobin/SCGB1A1	WB, ELISA	Uteroglobin / SCGB1A1 Antibody (Antigen Affinity Purified)	10808-RP02

Uteroglobin / SCGB1A1 cDNA Clone

Molecule	Species	Description	Cat. No
Uteroglobin/SCGB1A1	Human	Human Uteroglobin/SCGB1A1 cDNA Clone / ORF Clone	HG10808-M
Uteroglobin/SCGB1A1	Mouse	Mouse Uteroglobin/SCGB1A1 cDNA Clone / ORF Clone	MG50291-M

Uteroglobin / SCGB1A1 Alternative Names

Uteroglobin, SCGB1A1, CC10, CC16, CCPBP, CCSP, UGB, UP-1, UP1 [Homo sapiens]

Uteroglobin, Scgb1a1, CC10, CC16, CCSP, PCB-BP, UG, UGB, Utg [Mus musculus]

Uteroglobin / SCGB1A1 Background

Uteroglobin (UG), also known as Secretoglobin 1A member 1 (SCGB1A1), Blastokinin, Clara cell secretor protein (CCSP) or Clara cell-specific 10-kDa protein (CC10), is the founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals. This protein is mainly expressed in lung, with anti-inflammatory/immunomodulatory properties. Previous in vitro studies demonstrated that CCAAT/enhancer-binding proteins (C/EBPs) are the major transcription factors for the regulation of SCGB1A1 gene expression, whereas FOXA1 had a minimum effect on the transcription. Uteroglobin is a multifunctional protein with antiinflammatory/immunomodulatory properties. Uteroglobin inhibits soluble phospholipase A(2) activity and binds and perhaps sequesters hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids, and prostaglandins. In addition to its antiinflammatory activities, Uteroglobin manifests antichemotactic, antiallergic, antitumorigenic, and embryonic growth-stimulatory activities. The tissue-specific expression of the Uteroglobin gene is regulated by several steroid hormones, although a nonsteroid hormone, prolactin, further augments its expression in the uterus. Based on its anti-inflammatory and antiallergic properties, Uteroglobin is a potential drug target. The mechanism of Uteroglobin action is likely to be even more complex as it also functions via a putative receptor-mediated pathway.

Uteroglobin / SCGB1A1 Related Studies

1. Mukherjee AB, et al. (1999). Uteroglobin: a novel cytokine? Cell Mol Life Sci. 55(5): 771-87.
2. Klug J, et al. (2000). Uteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report. Ann. N. Y. Acad. Sci. 923: 348-54.
3. Laukaitis CM, et al. (2005). Evolution of the secretoglobins: a genomic and proteomic view. Biological Journal of the Linnean Society. 84 (3): 493-501.
4. Mukherjee AB, et al. (2007). Uteroglobin: a steroid-inducible immunomodulatory protein that founded the Secretoglobin superfamily. Endocr Rev. 28(7): 707-25.
5. Kido T, et al. (2011). FOXA1 plays a role in regulating secretoglobin 1a1 expression in the absence of CCAAT/enhancer binding protein activities in lung in vivo. Am J Physiol Lung Cell Mol Physiol. 300(3): L441-52.