Anti-Uteroglobin Antibody

Cat: 10808-RP02
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Anti-Uteroglobin Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Uteroglobin Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Uteroglobin
Immunogen
Recombinant Human Uteroglobin / SCGB1A1 protein (Catalog#10808-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human Uteroglobin / SCGB1A1 (rh Uteroglobin / SCGB1A1; Catalog#10808-H08H; P11684; Met 1-Asn 91). Uteroglobin / SCGB1A1 specific IgG was purified by Human Uteroglobin / SCGB1A1 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Uteroglobin Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Uteroglobin Antibody Alternative Names
Anti-CC10 Antibody;Anti-CC16 Antibody;Anti-CCPBP Antibody;Anti-CCSP Antibody;Anti-UGB Antibody;Anti-UP-1 Antibody;Anti-UP1 Antibody
Uteroglobin Background Information

Uteroglobin (UG), also known as Secretoglobin 1A member 1 (SCGB1A1), Blastokinin, Clara cell secretor protein (CCSP) or Clara cell-specific 10-kDa protein (CC10), is the founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals. This protein is mainly expressed in lung, with anti-inflammatory/immunomodulatory properties. Previous in vitro studies demonstrated that CCAAT/enhancer-binding proteins (C/EBPs) are the major transcription factors for the regulation of SCGB1A1 gene expression, whereas FOXA1 had a minimum effect on the transcription. Uteroglobin is a multifunctional protein with antiinflammatory/immunomodulatory properties. Uteroglobin inhibits soluble phospholipase A(2) activity and binds and perhaps sequesters hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids, and prostaglandins. In addition to its antiinflammatory activities, Uteroglobin manifests antichemotactic, antiallergic, antitumorigenic, and embryonic growth-stimulatory activities. The tissue-specific expression of the Uteroglobin gene is regulated by several steroid hormones, although a nonsteroid hormone, prolactin, further augments its expression in the uterus. Based on its anti-inflammatory and antiallergic properties, Uteroglobin is a potential drug target. The mechanism of Uteroglobin action is likely to be even more complex as it also functions via a putative receptor-mediated pathway.

Full Name
secretoglobin, family 1A, member 1 (uteroglobin)
References
  • Mukherjee AB, et al. (1999). Uteroglobin: a novel cytokine? Cell Mol Life Sci. 55(5): 771-87.
  • Klug J, et al. (2000). Uteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report. Ann. N. Y. Acad. Sci. 923: 348-54.
  • Laukaitis CM, et al. (2005). Evolution of the secretoglobins: a genomic and proteomic view. Biological Journal of the Linnean Society. 84 (3): 493-501.
  • Mukherjee AB, et al. (2007). Uteroglobin: a steroid-inducible immunomodulatory protein that founded the Secretoglobin superfamily. Endocr Rev. 28(7): 707-25.
  • Kido T, et al. (2011). FOXA1 plays a role in regulating secretoglobin 1a1 expression in the absence of CCAAT/enhancer binding protein activities in lung in vivo. Am J Physiol Lung Cell Mol Physiol. 300(3): L441-52.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Uteroglobin Antibody Rabbit Monoclonal ELISA 50291-R027
    Anti-Uteroglobin Antibody Rabbit Monoclonal IHC-P 50291-R122
    Anti-Uteroglobin Antibody Rabbit Monoclonal ELISA 50291-R016
    Anti-Uteroglobin Antibody Rabbit Polyclonal ELISA 50291-RP01
    Anti-Uteroglobin Antibody Rabbit Polyclonal ELISA 50291-T16
    Anti-Uteroglobin Antibody Mouse Monoclonal IHC-P 10808-MM06
    Anti-Uteroglobin Antibody Rabbit Polyclonal ELISA 10808-RP01
    Anti-Uteroglobin Antibody Rabbit Monoclonal ELISA 10808-R030
    Anti-Uteroglobin Antibody Rabbit Monoclonal FCM 10808-R135
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