|Catalog||Size (Price)||Quantity||In Stock||Operation||Other Information|
Ubiquitin specific peptidase 46 Protein Datasheet
USP46 Protein Price Inquiry ( Available Sizes )
USP46 Protein Product Information
A DNA sequence encoding the human USP46 (P80075-1) (Met1-Glu366) was fused with the SUMO tag at the N-terminus.
|Expression Host:||Baculovirus-Insect cells|
USP46 Protein QC Testing
|Purity:||> 90 % as determined by SDS-PAGE||SDS-PAGE:
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Met|
The secreted recombinant human USP46 consists of 477 amino acids and predicts a molecular mass of 55.2 KDa. The apparent molecular mass of the protein is approximately 64 Kda in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile 20mM Tris,500mM NaCl, pH 7.4, 10%gly.
USP46 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
USP46 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat No|
|USP46||Human||USP46 Protein, Recombinant||12976-HNCB|
|USP46||Human||USP46 Protein, Recombinant, with N-SUMO||12976-H21B|
USP46 Protein Description
USP46 is a member of the peptidase C19 family, USP12/USP46 subfamily. USP46 is a deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. Deubiquitinating enzymes (DUBs) are a large group of proteases which are also commonly referred to as deubiquitinating peptidases, deubiquitinating isopeptidases, deubiquitinases, ubiquitin proteases, ubiquitin hydrolyases, ubiquitin isopeptidases, or Dubs. They regulate ubiquitin-dependent metabolic pathways by cleaving ubiquitin-protein bonds. They also may act as negative and positive regulators of the ubiquitin system. USP46 is broadly expressed. It may act by mediating the deubiquitination of GAD1/GAD67. USP46 has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity and it is not involved in deubiquitination of monoubiquitinated FANCD2.
- Joo HY. et al., 2011, J Biol Chem. 286 (9): 7190-201.
- Kushima I. et al., 2010, J Hum Genet. 55 (3): 133-6.
- Cohn MA. et al., 2009, J Biol Chem. 284 (8): 5343-51.