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ULBP2 Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells
  • Slide 1
12143-H08H-50
12143-H08H-100
50 µg / $178
100 µg / $298
Add to Cart
Expression host: Human Cells
  • Slide 1
12143-H02H-50
12143-H02H-100
50 µg / $178
100 µg / $248
Add to Cart

ULBP2 Related Areas

ULBP2 Related Pathways

ULBP2 Related Product

    ULBP2 Summary & Protein Information

    ULBP2 Background

    Subunit structure: Interacts with the CMV glycoprotein UL16. Does not bind to beta2-microglobulin.
    Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor. Secreted.
    Tissue specificity: Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.
    Sequence similarity: Belongs to the MHC class I family.C
    General information above from UniProt

    NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein which belongs to the MHC class I family. ULBP2 / N2DL-2 is expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. ULBP2 / N2DL-2 is a ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway.

    ULBP2 Alternative Name

    N2DL2,RAET1H,ULBP2,UNQ463/PRO791, [human]

    ULBP2 Related Studies

  • Cosman D. et al., 2001,Immunity 14:123-133
  • Cerwenka A., et al., 2003, Tissue Antigens 61:335-343
  • Chang,Y.T. et al., 2011, PLoS One. 6 (5):e20029
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