|Recombinant Human ULBP2 / N2DL-2 protein (Catalog#12143-H08H)|
|0.2 μm filtered solution in PBS with 5% trehalose|
|Produced in rabbits immunized with purified, recombinant Human ULBP2 / N2DL-2 (rh ULBP2 / N2DL-2; Catalog#12143-H08H; Q9BZM5; Met 1-Ser 217). ULBP2 / N2DL-2 specific IgG was purified by Human ULBP2 / N2DL-2 affinity chromatography.|
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human ULBP2. The detection limit for Human ULBP2 is approximately 0.039 ng/well.
IHC-P: 0.5-2 μg/mL
NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein which belongs to the MHC class I family. ULBP2 / N2DL-2 is expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. ULBP2 / N2DL-2 is a ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway.