Anti-ULBP2 Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Human
Recombinant Human ULBP2 / N2DL-2 protein (Catalog#12143-H08H)
Produced in rabbits immunized with purified, recombinant Human ULBP2 / N2DL-2 (rh ULBP2 / N2DL-2; Catalog#12143-H08H; Q9BZM5; Met 1-Ser 217). ULBP2 / N2DL-2 specific IgG was purified by Human ULBP2 / N2DL-2 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-ULBP2 Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-ULBP2 Antibody (Rabbit Polyclonal antibody) Images
Immunochemical staining of human ULBP2 in human renal-carcinoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Anti-ULBP2 Antibody Alternative Names
Anti-ALCAN-alpha Antibody;Anti-N2DL2 Antibody;Anti-NKG2DL2 Antibody;Anti-RAET1H Antibody;Anti-UNQ463 / PRO791 Antibody
ULBP2 Background Information
NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein which belongs to the MHC class I family. ULBP2 / N2DL-2 is expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. ULBP2 / N2DL-2 is a ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway.
UL16 binding protein 2
Cosman D. et al., 2001,Immunity 14:123-133 Cerwenka A., et al., 2003, Tissue Antigens 61:335-343 Chang,Y.T. et al., 2011, PLoS One. 6 (5):e20029