Anti-ULBP2 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-ULBP2 Antibody
Validated applications
IHC-P
Species reactivity
Reacts with: Human
Specificity
Human ULBP2
No cross-reactivit y in ELISA with
Human ULBP1
Immunogen
Recombinant Human ULBP2 / N2DL-2 protein (Catalog#12143-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human ULBP2 / N2DL-2 (rh ULBP2 / N2DL-2; Catalog#12143-H08H; Q9BZM5; Met1-Ser217).
Source
Monoclonal Rabbit IgG Clone #022
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-ULBP2 Antibody (Rabbit Monoclonal antibody) Validated Applications
| Application |
Dilution |
Notes |
| IHC-P |
1:100-1:500 |
|
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-ULBP2 Antibody (Rabbit Monoclonal antibody) Images
Immunochemical staining of human ULBP2 in human renal carcinoma with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Immunochemical staining of human ULBP2 in human hepatoma with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Immunochemical staining of human ULBP2 in human gastric cancer with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Anti-ULBP2 Antibody Alternative Names
Anti-ALCAN-alpha Antibody;Anti-N2DL2 Antibody;Anti-NKG2DL2 Antibody;Anti-RAET1H Antibody;Anti-UNQ463 / PRO791 Antibody
ULBP2 Background Information
NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein which belongs to the MHC class I family. ULBP2 / N2DL-2 is expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. ULBP2 / N2DL-2 is a ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway.
Full Name
UL16 binding protein 2
References
Cosman D. et al., 2001,Immunity 14:123-133 Cerwenka A., et al., 2003, Tissue Antigens 61:335-343 Chang,Y.T. et al., 2011, PLoS One. 6 (5):e20029
