ULBP1

ULBP1 is ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. ULBP1 binds of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells,ULBP1 interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

ULBP1 Related Areas

Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>ULBP1

ULBP1 Alternative Names

ULBP1, RAET1I, N2DL1 [Homo sapiens]

ULBP1, A430108B07Rik, MULT1 [Mus musculus]

Summaries for ULBP1

Wikipedia summary for ULBP1:

NKG2D ligand 1 is a protein that in humans is encoded by the ULBP1 gene.[1][2][3]. It is a stress induced ligand for the NK cell activating receptor NKG2D.

Human ULBP1 Protein General Information

 

• Protein names: UL16-binding protein 1
  Short name= ULBP1
• Sequence length: 244 AA.
• Domain: Signal
• Sequence similarities: Belongs to the MHC class I family.
• Miscellaneous: The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain the alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides.
• Subunit structure: Interacts with the CMV glycoprotein UL16. Does not bind to beta2-microglobulin.
• Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor. Endoplasmic reticulum. Note: Detected intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts.
• Tissue specificity: Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.

General information above from UniProt

Function for ULBP1 Protein

UniProtKB:

ULBP1 is ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. ULBP1 binds of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells,ULBP1 interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Homology for human ULBP1

• homolog to ulbp2
• homolog to ulbp3