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UCHL3 Antibody, Rabbit MAb

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Rat UCHL3 Antibody Product Information
Immunogen:Recombinant Rat UCHL3 protein (Catalog#80087-R07E)
Clone ID:007
Ig Type:Rabbit IgG
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Rat UCHL3 (rR UCHL3; Catalog#80087-R07E; Q91Y78; Glu2-Ala230).
Rat UCHL3 Antibody Usage Guide
Specificity:Rat UCHL3
Has cross-reactivity in ELISA with
Human UCHL3
Mouse UCHL3
Application:WB, ELISA, IHC-P, IP

WB: 2-5 μg/mL

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Rat UCHL3. The detection limit for Rat UCHL3 is approximately 0.0049 ng/well.

IHC-P: 1-10 μg/mL

IP: 1-4 μg/mg of lysate

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Rat UCHL3 Antibody WB Application Image
Rat UCHL3 Antibody IHC Application Image
UCHL3 Antibody, Rabbit MAb, Immunohistochemistry
[Click to enlarge image]
Immunochemical staining of rat UCHL3 in rat testis with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
Rat UCHL3 Antibody IP Application Image
Other UCHL3 Antibody Products
UCHL3 Background

Ubiquitin carboxyl-terminal hydrolase isozyme L3, also known as UCH-L3, Ubiquitin thioesterase L3 and UCHL3, is a ubiquitin-protein hydrolase which belongs to the peptidase C12 family. It is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. UCHL3 is highly expressed in heart, skeletal muscle, and testis. UCHL1 and UCHL3 are two of the deubiquitinating enzymes expressed in the brain. These phenotypes indicate the importance of UCHL1 and UCHL3 in the regulation of the central nervous system. UCHL3 functions as a de-ubiquitinating enzyme where lack of its hydrolase activity may result in the prominent accumulation of ubiquitinated proteins and subsequent induction of stress responses in skeletal muscle. UCHL3 has also been identified as a tumor-specific antigen in colon cancer.

Rat UCHL3 References
  • Wood,M.A. et al., 2005, Hippocampus  15 (5):610-21.
  • Kwon,J. et al., 2006, Exp Anim  55 (1):35-43.
  • Setsuie,R. et al., 2009, Neurochem Int  54 (5-6):314-21.
  • Setsuie,R. et al., 2010, Neurochem Int  56 (8):911-8.
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    Size / Price
    Catalog: 80087-R007-50
    List Price: 
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    50 µg
    100 µg
    AvailabilityIn Stock
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    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.