UBE2H

UBE2H is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To deal with this complexity and to allow adequate ubiquitination in time and space, a highly sophisticated conjugation machinery has been developed. In a sequential manner, ubiquitin becomes activated by an ubiquitin-activating enzyme (E1), which then transfers the ubiquitin to a group of ubiquitin-conjugating enzymes (E2s). Next, ubiquitin-loaded E2s are interacting with ubiquitin protein ligases (E3s) and ubiquitin is conjugated to substrates on recruitment by the E3. These three key enzymes are operating in a hierarchical system, wherein two E1s and 35 E2s have been found and hundreds of E3s have been identified in humans.

UBE2H Related Areas

Enzyme>>Protease & Regulator>>Other Proteases>> UBE2H

Neuroscience>>Neurodegenerative Disease>>Ubiquitin-proteasome pathway>> UBE2H

UBE2H Alternative Names

E2-20K, UBC8, UBCH, UBCH2 [Homo sapiens]

1500009C23Rik, AI181839, AI326965, AI462483, AW227540, E2-20K, N28148, Ubc8 [Mus musculus]

Summaries for UBE2H

Entrez Gene summary for UBE2H:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2H gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for UBE2H gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]

Wikipedia summary for UBE2H:

Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.

Human UBE2H Protein General Information

 

• Protein names: Ubiquitin-conjugating enzyme E2 H
  Short name=UBE2H
• Sequence length: 183 AA.
• Pathway: Protein modification; protein ubiquitination.
• Sequence similarities: Belongs to the ubiquitin-conjugating enzyme family.
• Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

General information above from UniProt

Function for UBE2H Protein

UniProtKB:

UBE2H accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.

Genatlas:

• UBE2H is ubiquitin conjugating enzyme H2A

Homology for human UBE2H

• homolog to yeast UBC8