UBE2G1

UBE2G1 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To deal with this complexity and to allow adequate ubiquitination in time and space, a highly sophisticated conjugation machinery has been developed. In a sequential manner, ubiquitin becomes activated by an ubiquitin-activating enzyme (E1), which then transfers the ubiquitin to a group of ubiquitin-conjugating enzymes (E2s). Next, ubiquitin-loaded E2s are interacting with ubiquitin protein ligases (E3s) and ubiquitin is conjugated to substrates on recruitment by the E3. These three key enzymes are operating in a hierarchical system, wherein two E1s and 35 E2s have been found and hundreds of E3s have been identified in humans.

UBE2G1 Related Areas

Enzyme>>Protease & Regulator>>Other Proteases>> UBE2G1

Neuroscience>>Neurodegenerative Disease>>Ubiquitin-proteasome pathway>> UBE2G1

UBE2G1 Alternative Names

E217K, UBC7, UBE2G [Homo sapiens]

RP23-32B6.1, 2700059C12Rik, AI256795, AU014992, AW552068, D130023C12Rik [Mus musculus]

Summaries for UBE2G1

Entrez Gene summary for UBE2G1:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2G1 gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008]

Wikipedia summary for UBE2G1:

Ubiquitin-conjugating enzyme E2 G1 is a protein that in humans is encoded by the UBE2G1 gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins.

Human UBE2G1 Protein General Information

 

• Protein names: Ubiquitin-conjugating enzyme E2 G1
  Short name=UBE2G1
• Sequence length: 170 AA.
• Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
• Sequence similarities: Belongs to the ubiquitin-conjugating enzyme family.
• Pathway: Protein modification; protein ubiquitination.
• Sequence caution: The sequence AAH26288.2 differs from that shown. Reason: Erroneous initiation.
• Tissue specificity: Widely expressed, mainly in skeletal muscle.

General information above from UniProt

Function for UBE2G1 Protein

UniProtKB:

UBE2G1 accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. UBE2G1 may be involved in degradation of muscle-specific proteins. UBE2G1 mediates polyubiquitination of CYP3A4.

Genatlas:

• UBE2G1 catalyzes the covalent attachment of ubiquitin to other proteins
• UBE2G1 may be involved in degradation of muscle-specific proteins
• UBE2G1 modulates the transcriptional activity of progesterone receptor (PR) and glucocorticoid, androgen, and retinoic acid receptors in a hormone-dependent manner
• UBE2G1 plays a possible role in steroid receptor transactivation
• UBE2G1 participates in ERAD
• UBE2G1 and UBE2G2 cooperate with IL17RB to polyubiquitylate and degrade CDT1 postradiation, an activity that is critical for preventing origin licensing in DNA-damaged cells

Homology for human UBE2G1

• homolog to C.elegans UBC7