Tyrosine Hydroxylase Protein

Tyrosine Hydroxylase Products

Tyrosine Hydroxylase Protein, Recombinant

Molecule	Species	Description	Cat. No
Tyrosine Hydroxylase	Human	TH / Tyrosine Hydroxylase Protein, Recombinant	10684-H07B
Tyrosine Hydroxylase	Mouse	TH / Tyrosine Hydroxylase Protein, Recombinant	50997-M07B

Tyrosine Hydroxylase cDNA Clone

Molecule	Species	Description	Cat. No
Tyrosine Hydroxylase	Human	Tyrosine Hydroxylase cDNA Clone / ORF Clone	HG10684-M
Tyrosine Hydroxylase	Mouse	Tyrosine Hydroxylase cDNA Clone / ORF Clone	MG50997-G

Tyrosine Hydroxylase Related Areas

Enzyme>>Other>>Tyrosine Hydroxylase

Tyrosine Hydroxylase Alternative Names

Tyrosine Hydroxylase, TH, DYT14, DYT5b, TYH [Homo sapiens]

Tyrosine Hydroxylase, Th, OTTMUSP00000020341, tyrosine 3-hydroxylase, tyrosine 3-monooxygenase [Mus musculus]

Tyrosine Hydroxylase Background

Tyrosine hydroxylase (TH) is a rate-limiting enzyme in catecholamine synthesis. Tyrosine hydroxylase activity is modulated by protein-protein interactions with enzymes in the same pathway or the tetrahydrobiopterin pathway, structural proteins considered to be chaperones that mediate the neuron's oxidative state, and the protein that transfers dopamine into secretory vesicles. It is phosphorylated at serine (Ser) residues Ser8, Ser19, Ser31 and Ser40 in vitro. The phosphorylation of tyrosine hydroxylase at Ser19 or Ser8 has no direct effect on tyrosine hydroxylase activity. As tyrosine hydroxylase (TH) catalyses the formation of L-DOPA, the rate-limiting step in the biosynthesis of DA, the Parkinson's disease (PD) can be considered as a TH-deficiency syndrome of the striatum. A direct pathogenetic role of TH has also been suggested, as the enzyme is a source of reactive oxygen species (ROS) in vitro and a target for radical-mediated oxidative injury. Recently, it has been demonstrated that L-DOPA is effectively oxidized by mammalian Tyrosine hydroxylase in vitro, possibly contributing to the cytotoxic effects of DOPA.

Tyrosine Hydroxylase Related Studies

1. Daubner SC, et al. (2011) Tyrosine hydroxylase and regulation of dopamine synthesis. Arch Biochem Biophys. 508(1): 1-12.
2. Dunkley PR, et al. (2004) Tyrosine hydroxylase phosphorylation: regulation and consequences. J Neurochem. 91(5): 1025-43.
3. Haavik J, et al. (1998) Tyrosine hydroxylase and Parkinson's disease. Mol Neurobiol. 16(3): 285-309.