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Tumor Necrosis Factor & Receptor

Tumor Necrosis Factor (TNF) Background

What is Tumor Necrosis Factor (TNF)
Tumor necrosis factors (TNF family) refer to a group of cytokines which are mainly secreted by macrophages and can induce cell death of certain tumor cell lines. The first two members of the family to be identified were: Tumor Necrosis Factor Alpha (TNF Alpha) and Tumor necrosis factor-beta (TNF-β), also known as Lymphotoxin-alpha, a cytokine that is inhibited by interleukin 10. Learn More.

Tumor Necrosis Factor (TNF) Inhibitors
Tumor necrosis factor (TNF) promotes the inflammatory response, which in turn causes many of the clinical problems associated with autoimmune disorders such as rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, psoriasis, hidradenitis suppurativa and refractory asthma. These disorders are sometimes treated by using a TNF inhibitor, also known as TNF blocker. Learn More.

Tumor Necrosis Factor (TNF) Signaling Pathway
The tumor necrosis factor (TNF) superfamily of cytokines activate signaling pathways for cell survival, death, and differentiation. Members of the tumor necrosis factor superfamily act through ligand-mediated trimerization, causing recruitment of several intracellular adaptors to activate multiple signal transduction pathways. Recruitment of death domain (DD) containing adaptors such as Fas associated death domain (FADD) and TNFR associated DD (TRADD) can lead to the activation of a signal transduction pathway that induces apoptosis. While recruitment of TRAF family proteins can lead to the activation of transcription factors such as, NF-kappaB and JNK thereby promoting cell survival and differentiation as well as immune and inflammatory responses. Learn More.

Anti TNF Therapy / Anti TNF Drugs
Tumoral necrosis factor α plays a central role in both the inflammatory response and that of the immune system. Thus, its blockade with the so-called anti TNF drugs / agents has turned into the most important tool in the management of a variety of disorders, such as rheumatoid arthritis, spondyloarthropatties, inflammatory bowel disease, and psoriasis. Learn More.

Tumor Necrosis Factor (TNF) References
  1. Dempsey PW, et al. (2003) The signaling adaptors and pathways activated by TNF superfamily. Cytokine Growth Factor Rev. 14(3-4):193-209.
  2. Ware CF. (2003) The TNF superfamily. Cytokine Growth Factor Rev. 14(3-4):181-4.
  3. Kishore U, et al. (2004) C1q and tumor necrosis factor superfamily: modularity and versatility. Trends Immunol. 25(10):551-61.
  4. Wang Y, et al. (2009) Immunoregulation by tumor necrosis factor superfamily member LIGHT. Immunol Rev. 229(1):232-43.

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    Tumor Necrosis Factor & Receptor Background

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