_×
Tryptophan Hydroxylase 1 / TPH1 Antibody, Rabbit PAb, Antigen Affinity Purified
  0 products, total $0.+86-400-890-9989      Login |  Register 中文한국어

Browse By Molecule:

Your Position: Home > Antibody > Rabbit PAb Antibody > Tryptophan Hydroxylase 1 / TPH1 Antibody, Rabbit PAb, Antigen Affinity Purified

Tryptophan Hydroxylase 1 / TPH1 Antibody, Rabbit PAb, Antigen Affinity Purified PDF Download

Catalog   Size (Price) Quantity In Stock Operation
11931-RP02  

YES   
 

Primary antibody | Secondary antibody | Tag antibody | Isotype control antibody | Loading control antibody | Antibody Purification

Tryptophan Hydroxylase 1 / TPH1 Antibody ( Antigen Affinity Purified ) Datasheet

  Order or Inquire for Tryptophan Hydroxylase 1 / TPH1 Antibody product Quality antibodies Antibody production services
  Detection limit is 0.00975 ng/well in ELISA
 

Tryptophan Hydroxylase 1 / TPH1 Antibody Product Information

Immunogen :

Recombinant Human Tryptophan Hydroxylase 1 / TPH1 protein (Catalog#11931-H07E)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type :

Rabbit IgG

Formulation : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
Preparation :

Produced in rabbits immunized with purified, recombinant Human Tryptophan Hydroxylase 1 / TPH1 (rh Tryptophan Hydroxylase 1 / TPH1; Catalog#11931-H07E; P17752-1; Ile 2-Ile 444). Tryptophan Hydroxylase 1 / TPH1 specific IgG was purified by Human Tryptophan Hydroxylase 1 / TPH1 affinity chromatography.

Tryptophan Hydroxylase 1 / TPH1 Antibody Usage Guide

Specificity :

Human Tryptophan Hydroxylase 1 / TPH1

Direct ELISA : This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human TPH1. The detection limit for Human TPH1 is approximately 0.00975 ng/well.
Storage : This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Tryptophan Hydroxylase 1 / TPH1 Antibody Related Products & Topics

Related Areas:

Proteins:

Antibodies:

Tryptophan Hydroxylase 1 / TPH1 Antibody Background

Tryptophan 5-hydroxylase 1, also known as Tryptophan 5-monooxygenase 1, Tryptophan hydroxylase 1, TPH1, TPH and TPRH, is anenzyme which belongs to thebiopterin-dependent aromatic amino acid hydroxylase family. TPH1 contains oneACT domain. Tryptophan hydroxylase catalyzes the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. TPH1 expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells.The tryptophan hydroxylase 1 (TPH1) gene is also reported to be associated with suicidal behavior. Polymorphisms of TPH1 may assist in identifying a subgroup of mood disorder patients that is at higher risk for suicidal behavior.

References

  1. Antonia S. New, et al.,1998, American Journal of Medical Genetics Part B. 81 (1): 13-17.
  2. Y. C Wang, et al.,2001, Neuropsychobiology. 43 (1): 1-4.
  3. Diego J. et al., 2003, Science. 299 (5603): 76.
  4. Allen NC, et al.,2008, Nat Genet.40 (7): 827-34.
  5. Galfalvy,H. et al., 2009, J Affect Disord. 115 (3): 331-8.
 

 

TPH1 related areas, pathways, and other information

 

Primary Antibody Products

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"