Trypsin-3 (PRSS3)

Trypsin-3 is digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, Trypsin-3 may be involved in defensin processing, including DEFA5.

Trypsin-3 (PRSS3) Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Trypsin / PRSS>>Trypsin-3/PRSS3

Trypsin-3 (PRSS3) Alternative Names

Trypsin-3, PRSS3, RP11-176F3.3, MTG, PRSS4, T9, TRY3, TRY4 [Homo sapiens]

Trypsin-3, Prss3, MGC176265, MTG, TRY4, Tb, Try3 [Mus musculus]

Summaries for Trypsin-3 (PRSS3)

Entrez Gene summary for Trypsin-3 (PRSS3):

PRSS3 gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. PRSS3 gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for PRSS3 gene. [provided by RefSeq, Oct 2010]

OMIM - description for Trypsin-3 (PRSS3):

Serine proteases are endopeptidases that are involved in multiple biologic processes, including proteolytic processing of proteins, digestion, blood coagulation, immune response, and development. Trypsin-like serine proteases (EC 3.4.21.4), such as PRSS3, catalyze the hydrolysis of peptide bonds on the carboxyl side of lysine or arginine residues (summary by Wiegand et al., 1993).

Human Trypsin-3 (PRSS3) Protein General Information

 

• Protein names: Trypsin-3
• Sequence length: 304 AA.
• Domain: Signal
• Sequence similarities: Belongs to the peptidase S1 family.
  Contains 1 peptidase S1 domain.
• Cofactor: Binds 1 calcium ion per subunit.
• Subcellular location: Secreted.
• Tissue specificity: Expressed in pancreas and brain. Also expressed in Paneth cells, at the base of small intestinal crypts.
• Catalytic activity: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

General information above from UniProt

Function for Trypsin-3 (PRSS3) Protein

UniProtKB:

Trypsin-3 is digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, Trypsin-3 may be involved in defensin processing, including DEFA5.

Genatlas:

• Trypsin-3 is protease serine, cationic trypsinogen
• Trypsin-3 is preferential cleavage arg-xaa and lys-xaa

Homology for human Trypsin-3 (PRSS3)

• homolog to C.elegans c07g1.1