Anti-PRSS3 Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Human
Recombinant Human Trypsin-3 / PRSS3 protein (Catalog#11866-H08H)
Produced in rabbits immunized with purified, recombinant Human Trypsin-3 / PRSS3 (rh Trypsin-3 / PRSS3; Catalog#11866-H08H; P35030-3; Met 1-Ser 247). Trypsin-3 / PRSS3 specific IgG was purified by Human Trypsin-3 / PRSS3 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PRSS3 Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-PRSS3 Antibody Alternative Names
Anti-MTG Antibody;Anti-PRSS4 Antibody;Anti-RP11-176F3.3 Antibody;Anti-T9 Antibody;Anti-TRY3 Antibody;Anti-TRY4 Antibody
PRSS3 Background Information
Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein which belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their inhibitors seems to be important for the development of CP. The trypsin inhibitor-degrading activity qualified PRSS3 as a candidate for a novel CP susceptibility gene. Trypsin-3 / PRSS3 has been implicated as a putative tumor suppressor gene due to its loss of expression, which is correlated with promoter hypermethylation, in esophageal squamous cell carcinoma and gastric adenocarcinoma.
protease, serine 3
Venter JC. et al., 2001, Science 291:1304-51. Marsit,CJ. et al., 2005, Mol Carcinog 44 (2):146-50. Rowen, L. et al., 2005, Mol Biol Evol. 22 (8):1712-20. Rosendahl, J. et al., 2010, Pancreatology. 10 (2-3):243-9