Anti-PRSS3 Antibody

Cat: 11866-RP02
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Anti-PRSS3 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-PRSS3 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human PRSS3
Immunogen
Recombinant Human Trypsin-3 / PRSS3 protein (Catalog#11866-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human Trypsin-3 / PRSS3 (rh Trypsin-3 / PRSS3; Catalog#11866-H08H; P35030-3; Met 1-Ser 247). Trypsin-3 / PRSS3 specific IgG was purified by Human Trypsin-3 / PRSS3 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PRSS3 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-PRSS3 Antibody Alternative Names
Anti-MTG Antibody;Anti-PRSS4 Antibody;Anti-RP11-176F3.3 Antibody;Anti-T9 Antibody;Anti-TRY3 Antibody;Anti-TRY4 Antibody
PRSS3 Background Information

Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein which belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their inhibitors seems to be important for the development of CP. The trypsin inhibitor-degrading activity qualified PRSS3 as a candidate for a novel CP susceptibility gene. Trypsin-3 / PRSS3 has been implicated as a putative tumor suppressor gene due to its loss of expression, which is correlated with promoter hypermethylation, in esophageal squamous cell carcinoma and gastric adenocarcinoma.

Full Name
protease, serine 3
References
  • Venter JC. et al., 2001, Science 291:1304-51.
  • Marsit,CJ. et al., 2005, Mol Carcinog 44 (2):146-50.
  • Rowen, L. et al., 2005, Mol Biol Evol. 22 (8):1712-20.
  • Rosendahl, J. et al., 2010, Pancreatology. 10 (2-3):243-9
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-PRSS3 Antibody Rabbit Polyclonal ELISA 11866-RP01
    Anti-PRSS3 Antibody Rabbit Monoclonal ELISA 11866-R001
    info info
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