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Trophoblast Stem Cell Marker

Trophoblast stem cells (TSC) are the precursors of the differentiated cells of the placenta. The ability to self-renew of trophoblast stem cell depends on FGF4 signaling. Sino Biological provides a comprehensive set of tools for trophoblast stem cell marker related studies, including recombinant proteins, antibodies (rabbit MAb & PAb, mouse MAb), ELISA kits, and ORF cDNA clones.

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    Trophoblast Stem Cell Marker Background

    Trophoblast stem cells (TSC) are the precursors of the differentiated cells of the placenta. The blastocyst is made up of three main parts: the blastocoel (an internal, fluid-filled cavity), the inner cell mass (ICM), and the trophoblast. When the embryo was a morula, the surrounding trophoblast precursors caused fluid to be secreted into the morula (utilizing sodium pumps in the trophoblast cell membranes); this secretion created the blastocoel cavity. The ICM will later become the adult organism; human embryonic stem cells can be derived from the ICM. Lastly, the trophoblast is a monolayer of cells, specifically polarized epithelial cells, which surround the blastocoel and ICM, similar to their future role of surrounding the fetus as its placenta.

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