Anti-TrkC Antibody

Cat: 10048-R001
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Anti-TrkC Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-TrkC Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human TrkC
No cross-reactivity in ELISA with Human NTRK1 / Trk-A / TRK Human Trk-B / NTRK2 / TRKB Mouse Trk-C / TRKC / NTRK3
Immunogen
Recombinant Human Trk-C protein (Catalog#10048-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human Trk-C / NTRK3 (rh Trk-C; Catalog#10048-H08H; NP_001007157.1; Met 1-Asp 427).
Source
Monoclonal Rabbit IgG Clone #1
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-TrkC Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-TrkC Antibody Alternative Names
Anti-gp145(trkC) Antibody;Anti-TRKC Antibody
TrkC Background Information

NT-3 growth factor receptor also known as neurotrophic tyrosine kinase receptor type 3 or TrkC tyrosine kinase or Trk-C receptor, is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkC/NTRK3 is widely expressed in the developing and adult nervous system. In later embryonic development, TrkC/NTRK3 is expressed in various structures of the CNS including the caudatoputamen, septal nuclei, cerebellum, and brainstem. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. In the PNS, trkC hybridization appears to correlate, both temporally and spatially, with the outgrowth of axons toward their peripheral targets. TrkC/NTRK3 is widely expressed in the three identified branches of the mammalian nervous system and appears to correlate with the expression of NT-3, its cognate ligand. The apparent colocalization of trkC transcripts with NT-3 raises the possibility this neurotrophin exerts its trophic effects by a paracrine and/or autocrine mechanism. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in TrkC encoding gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
neurotrophic tyrosine kinase, receptor, type 3
References
  • Tessarollo L, et al. (1993) trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues. Development. 118(2): 463-75.
  • Lamballe F, et al. (1994) Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system. J Neurosci. 14(1): 14-28.
  • Klein R, et al. (1994) Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. Nature. 368(6468): 249-51.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-TrkC Antibody Rabbit Polyclonal ELISA 50320-RP02
    Anti-TrkC Antibody Rabbit Polyclonal ELISA 50320-RP01
    Anti-TrkC Antibody Rabbit Monoclonal ELISA 50320-R101
    Anti-TrkC Antibody Mouse Monoclonal ICC/IF,IF 10048-MM03
    Anti-TrkC Antibody Mouse Monoclonal ELISA(Det) 10048-MM08
    Anti-TrkC Antibody Rabbit Polyclonal ELISA 10048-RP01
    Anti-TrkC Antibody Rabbit Polyclonal ELISA 10048-RP02
    Anti-TrkC Antibody Mouse Monoclonal ELISA(Cap) 10048-MM11
    Anti-TrkC Antibody Rabbit Monoclonal ELISA 10048-R005
    Anti-TrkC Antibody (PE) Mouse Monoclonal FCM 10048-MM03-P
    Anti-TrkC Antibody Mouse Monoclonal ELISA 10048-MM06
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