All TrkB reagents are produced in house and quality controlled, including 5 TrkB Antibody, 1 TrkB ELISA, 49 TrkB Gene, 7 TrkB Lysate, 7 TrkB Protein, 3 TrkB qPCR. All TrkB reagents are ready to use.
Recombinant TrkB proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His, C-human IgG1-Fc & His.
TrkBantibodies are validated with different applications, which are FCM, ELISA, ELISA(Det), WB.
TrkBcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each TrkB of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
TrkBELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptors with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in TrkB/NTRK have been associated with obesity and mood disorders.