Anti-TrkB Antibody

Cat: 10047-MM12
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Anti-TrkB Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-TrkB Antibody
Validated applications
Species reactivity
Reacts with: Human
Human TrkB
No cross-reactivity in ELISA with Human Trk-A / NTRK1 / TRK Human Trk-C / NTRK3 / TRKC Mouse Trk-C / NTRK3 / TRKC
Recombinant Human Trk-B protein (Catalog#10047-H08H)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human NTRK2 / Trk-B extracellular domain (rh Trk-B; Catalog#10047-H08H; NP_001007098.1; Met 1-His 430). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography .
Monoclonal Mouse IgG1 Clone #7H6E7B3
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-TrkB Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
FCM 1:25-1:100  
ELISA(Cap) 1:250-1:2000 This antibody will detect Human TrkB / NTRK2 in ELISA pair set (Catalog: # SEK10047). In a sandwich ELISA, it can be used as capture antibody when paired with (Catalog: # 10047-MM01).

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-TrkB Antibody (Mouse Monoclonal antibody) Images
Human TrkB/NTRK2 Flow Cytometry (FC) 5000
Flow cytometric analysis of Human TRKB expression on DU145 cells. Cells were stained with purified anti-Human TRKB, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Anti-TrkB Antibody Alternative Names
Anti-GP145-TrkB Antibody;Anti-GP145-TrkB/GP95-TrkB Antibody;Anti-Tkrb Antibody;Anti-trk-B Antibody;Anti-TRKB Antibody
TrkB Background Information

TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptors with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in TrkB/NTRK have been associated with obesity and mood disorders.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
neurotrophic tyrosine kinase, receptor, type 2
  • Klein R, et al. (1990) The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell. 61 (4): 647-56.
  • Rose CR, et al. (2003) Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells. Nature. 426 (6962): 74-8.
  • Yamada K, et al. (2004) Brain-derived neurotrophic factor/TrkB signaling in memory processes. J Pharmacol Sci. 91 (4): 267-70.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-TrkB Antibody Rabbit Monoclonal ELISA 10047-R107
    Anti-TrkB Antibody Mouse Monoclonal ELISA,ELISA(Det) 10047-MM01
    Anti-TrkB Antibody Rabbit Polyclonal ELISA 10047-RP01
    Anti-TrkB Antibody Rabbit Polyclonal ELISA 10047-RP02
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