Quick Order

TrkB / NTRK2 Antibody (PE), Mouse MAb

  • TrkB / NTRK2 Antibody (PE), Mouse MAb, Flow cytometric
DatasheetReviewsRelated ProductsProtocols
Human NTRK2 Antibody Product Information
Immunogen:Recombinant Human TrkB / NTRK2 protein (Catalog#10047-H08H)
Clone ID:12
Ig Type:Mouse IgG1
Concentration:5 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TrkB / NTRK2 (rh TrkB / NTRK2; Catalog#10047-H08H; NP_001007098.1; Met1-His430) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Human NTRK2 Antibody Usage Guide
Specificity:Human TrkB / NTRK2
Application:FCM
Storage:
Human NTRK2 Antibody FC Application Image
TrkB / NTRK2 Antibody (PE), Mouse MAb, Flow cytometric
[Click to enlarge image]
Caption:
Profile of anti-Human TRKB reactivity on DU145 cells analyzed by flow cytometry.
Other NTRK2 Antibody Products
TrkB/NTRK2 Background

TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptors with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in TrkB/NTRK have been associated with obesity and mood disorders.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Human TrkB/NTRK2 References
  • Klein R, et al. (1990) The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell. 61 (4): 647-56.
  • Rose CR, et al. (2003) Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells. Nature. 426 (6962): 74-8.
  • Yamada K, et al. (2004) Brain-derived neurotrophic factor/TrkB signaling in memory processes. J Pharmacol Sci. 91 (4): 267-70.
  • Product nameProduct name
    Size / Price
    Catalog: 10047-MM12-P-25
    List Price: 
    Price:      (You Save: )

    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"