TrkA / NTRK1 Protein & Antibody

Tyrosine Kinase Receptor A / Neurotrophic Tyrosine Kinase, Receptor, type 1

TrkA / NTRK1 Products

TrkA / NTRK1 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
TrkA/NTRK1	Human	TrkA/NTRK1/Fc Protein, Recombinant	11073-H03H
TrkA/NTRK1	Human	TrkA/NTRK1 Protein (aa 194-413), Recombinant	11073-H07H2
TrkA/NTRK1	Human	TrkA/NTRK1 Protein (aa 285-413), Recombinant	11073-H07E1
TrkA/NTRK1	Human	TrkA/NTRK1 Protein, Recombinant	11073-H08H
TrkA/NTRK1	Rat	TrkA / NTRK1 Protein, Recombinant	80404-R08H

11073-H03H : ED₅₀ = 0.04 - 0.15 μg / mL. Measured by its ability to inhibit NGF-induced proliferation of TF-1 human erythroleukemic cells.

11073-H08H : ED₅₀ = 60.4 μg / mL .Measured by its ability to inhibit NGF-induced proliferation of TF-1 human erythroleukemic cells.

11073-H07H2: The ED₅₀ for this effect is typically 2.84 µg/mL in the presence of 10 ng/mL of human NGF. Measured by its ability to inhibit NGF-induced proliferation of TF1 human erythroleukemic cells.

TrkA / NTRK1 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human TrkA/NTRK1	WB, ELISA	Mouse Monoclonal Antibody	11073-MM04
Human TrkA/NTRK1	WB, ELISA	Mouse Monoclonal Antibody	11073-MM09
Human TrkA/NTRK1	WB, ELISA	TrkA/NTRK1 Antibody, Rabbit MAb	11073-R001
Human TrkA/NTRK1	IHC-P	TrkA / NTRK1 Antibody	11073-R024
Human TrkA/NTRK1	WB, ELISA	Rabbit Polyclonal Antibody	11073-RP01
Human TrkA/NTRK1	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11073-RP02

TrkA / NTRK1 ELISA Kit

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human TrkA/NTRK1	ELISA	TrkA/NTRK1 ELISA Kit	SEK11073

TrkA / NTRK1 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
TrkA/NTRK1	Human	Homo sapiens TrkA/NTRK1 cDNA Clone	HG11073-M
TrkA/NTRK1	Mouse	Mouse NTRK1 Gene cDNA Clone / ORF Clone	MG51103-G
TrkA/NTRK1	Rat	NTRK1 cDNA Clone / ORF Clone	RG80404-G

TrkA / NTRK1 Alternative Names

TRKA, NTRK1, TRK, TRK1, DKFZp781I14186, MTC, p140-TrkA [Homo sapiens]

TrkA, NTRK1, Tkr, trk, C80751 [Mus musculus]

TrkA / NTRK1 Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>TrkA/NTRK1

Neuroscience>>Neurotrophic Factor & Receptor>>Neurotrophin & Receptor>>TrkA/NTRK1

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>TrkA/NTRK1

Cancer>>Growth Factor & Receptor>> Neurotrophin & Receptor>>TrkA/NTRK1

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>TrkA/NTRK1

TrkA / NTRK1 Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
NGF	Human	NGF Protein, Recombinant
TrkB/NTRK2	Human	TrkB/NTRK2/Fc Protein, Recombinant
TrkB/NTRK2	Human	TrkB/NTRK2 Protein, Recombinant
TrkB/NTRK2	Mouse	TrkB/NTRK2 Protein, Recombinant
TrkC/NTRK3	Human	TrkC/NTRK3/Fc Protein, Recombinant
TrkC/NTRK3	Human	TrkC/NTRK3 Protein, Recombinant
TrkC/NTRK3	Mouse	TrkC/NTRK3 Protein, Recombinant

Antibody Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
Human TrkB/NTRK2	WB	Mouse Monoclonal Antibody
Human TrkB/NTRK2	WB, ELISA, IHC	TrkB/NTRK2 Antibody, Rabbit MAb
Human TrkB/NTRK2	WB, ELISA	Rabbit Polyclonal Antibody
Human TrkB/NTRK2	WB, ELISA, IHC	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human TrkC/NTRK3	WB, ELISA	Mouse Monoclonal Antibody
Human TrkC/NTRK3	WB, ELISA	Rabbit Monoclonal Antibody
Human TrkC/NTRK3	WB, ELISA	Rabbit Polyclonal Antibody
Human TrkC/NTRK3	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Mouse TrkC/NTRK3	WB, ELISA	TrkC/NTRK3 Antibody, Rabbit PAb
Mouse TrkC/NTRK3	WB, ELISA	TrkC/NTRK3 Antibody, Rabbit PAb (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
BDNF	Human	Homo sapiens BDNF transcript variant 4 cDNA Clone(NM_001709.3)
Neurotrophin-3/NT-3	Human	Homo sapiens Neurotrophin-3/NT-3 transcript variant2 cDNA Clone(NM_002527.4)
Neurotrophin-4/NT-4	Human	Homo sapiens NT-4 cDNA Clone(NM_006179.4)
TrkB/NTRK2	Human	Homo sapiens TrkB/NTRK2 transcript variant b cDNA Clone(NM_001007097.1)
TrkB/NTRK2	Mouse	Mus musculus TrkB/NTRK2 cDNA Clone
TrkC/NTRK3	Human	Homo sapiens TrkC/NTRK3 transcript variant 3 cDNA Clone(NM_001007156.1)
TrkC/NTRK3	Mouse	Mus musculus TrkC/NTRK3 cDNA Clone

TrkA / NTRK1 Background

TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors. The presence of NTRK1 leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. It was originally identified as an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas. TRKA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. NTRK1 has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. It also activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway. Defects in NTRK1 are a cause of congenital insensitivity to pain with anhidrosis and thyroid papillary carcinoma.

TrkA / NTRK1 Related Studies

Lambiase A, et al. (2005) Molecular basis for keratoconus: lack of TrkA expression and its transcriptional repression by Sp3. Natl Acad Sci. 102 (46):16795-800.
Benito-Gutiérrez E, et al. (2006) Origin and evolution of the Trk family of neurotrophic receptors. Mol Cell Neurosci. 31(2):179-92.
Martin-Zanca D, et al. (1986) A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature. 319(6056):743-8.