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TrkA / NTRK1 Protein & Antibody

Tyrosine Kinase Receptor A / Neurotrophic Tyrosine Kinase, Receptor, type 1

TrkA / NTRK1 Products

TrkA / NTRK1 Protein

Human TrkA / NTRK1 Protein (11073-H03H) Activity assay
Tag: human IgG1-Fc
Expression host: Human Cells

Price/Size: $290 / 100µg order

 
Human TrkA / NTRK1 Protein (11073-H08H) Activity assay
Tag: His
Expression host: Human Cells
Price/Size: $290 / 100µgorder
 
Human TrkA / NTRK1 Protein (aa 285-413) (11073-H07E1) Activity assay
Tag: N-His
Expression host: E.Coli
Price/Size: $290 / 100µgorder
 
Human TrkA / NTRK1 Protein (aa 194-413) (11073-H07H2) Activity assay
Tag: N-His
Expression host:Human Cells
Price/Size: $290 / 100µgorder
 
Rat TrkA / NTRK1 Protein (80404-R08H) Activity assay
Tag: His
Expression host: Human Cells
Price/Size: $290 / 100µgorder
 
Mouse TrkA / NTRK1 Protein(51103-M02H) Activity assay
Tag: human IgG1-Fc
Expression host: Human Cells
Price/Size: $290 / 100µgorder
 
Mouse TrkA / NTRK1 Protein (51103-M08H) Activity assay
Tag: His
Expression host: Human Cells
Price/Size: $290 / 100µgorder
 
Rat TrkA / NTRK1 Protein(80404-R02H) Activity assay
Tag: human IgG1-Fc
Expression host: Human Cells
Price/Size: $290 / 100µgorder
 
Canine TrkA / NTRK1 Protein (70101-D01H) Activity assay
Tag: human IgG1-Fc
Expression host: Human Cells
Price/Size: $290 / 100µgorder
 
Canine TrkA / NTRK1 Protein (70101-D07H) Activity assay
Tag: untagged
Expression host: CHO Stable Cells
Price/Size: $290 / 100µgorder

TrkA / NTRK1 Antibody

Anti-human NTRK1 / Trk-A Antibody (11073-RP01)    
Host & Clone: Rabbit Pab
Application: WB, ELISA
Price/Size: $230 / 200µg
$135 / 100µg order
   
 
Anti-human NTRK1 / Trk-A Antibody (11073-RP02)    
Host & Clone: Rabbit Pab
Application: WB, ELISA
Price/Size: $230 / 100µg
$170 / 50µg order
   
 
Anti-human NTRK1 / Trk-A / TRKA Antibody (11073-MM04)    
Host & Clone: Mouse Mab
Application: ELISA
Price/Size: $290 / 100µg
$170 / 50µg order
   
 
Anti-human NTRK1 / Trk-A / TRKA Antibody (11073-MM09)    
Host & Clone:Mouse Mab
Application: WB
Price/Size: $230 / 100µg
$135 / 50µg order
   
 
Anti-human NTRK1 / Trk-A Antibody (11073-R001)    
Host & Clone: Rabbit Mab
Application: WB, ELISA
Price/Size: $290 / 100µg
$135 / 50µg order
   
 
Anti-human TrkA / NTRK1 Antibody (11073-R001)    
Host & Clone: Rabbit Mab
Application: IHC-P
Price/Size: $290 / 100µg
$170 / 50µg order
   

TrkA / NTRK1 Gene cDNA Clone

Rat TrkA / NTRK1 Gene cDNA Clone / ORF Clone (RG80404-G)
 
cDNA size: 2400bp order
Price (Cloning Vector): $195 (Cloning Vector)
Price (Expression Vector): $445  (pCMV / hygro)
$445 (pCMV / hygro - HA) $445 (pCMV / hygro - His) $445 (pCMV / hygro - Myc $445 (pCMV / hygro - FLAG)
 
Mouse NTRK1 Gene cDNA Clone / ORF Clone (MG51103-G)
 
cDNA size: 2400bp order
Price (Cloning Vector): $195 (cloning Vector)
Price (Expression Vector): $445  (pCMV / hygro)
$445 (pCMV / hygro - HA) $445 (pCMV / hygro - His) $445 (pCMV / hygro - Myc $445 (pCMV / hygro - FLAG)
 
Human TrkA / NTRK1 ORF Expression Clone, HA-tagged (DG70027-G)
 
cDNA size: 2421bp order
Price (Expression Vector):$545 (pCMV / hygro - HA)

TrkA / NTRK1 ELISA Kits

NTRK1 / Trk-A / TrkA ELISA Pair Set (SEK11073)
 
Type: HRP
Antigen-species: Human
Price/Size: $350 / 5 plate
$850 / 15 plateorder

TrkA / NTRK1 Alternative Names

TRKA, NTRK1, TRK, TRK1, DKFZp781I14186, MTC, p140-TrkA [Homo sapiens]

TrkA, NTRK1, Tkr, trk, C80751 [Mus musculus]

TrkA / NTRK1 Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>TrkA/NTRK1

Neuroscience>>Neurotrophic Factor & Receptor>>Neurotrophin & Receptor>>TrkA/NTRK1

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>TrkA/NTRK1

Cancer>>Growth Factor & Receptor>> Neurotrophin & Receptor>>TrkA/NTRK1

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>TrkA/NTRK1

TrkA / NTRK1 Related Products

Protein Products

Molecule Species Description //For Detailed Info. and Price------CLICK!
NGF Human NGF Protein, Recombinant
TrkB/NTRK2 Human TrkB/NTRK2/Fc Protein, Recombinant
TrkB/NTRK2 Human TrkB/NTRK2 Protein, Recombinant
TrkB/NTRK2 Mouse TrkB/NTRK2 Protein, Recombinant
TrkC/NTRK3 Human TrkC/NTRK3/Fc Protein, Recombinant
TrkC/NTRK3 Human TrkC/NTRK3 Protein, Recombinant
TrkC/NTRK3 Mouse TrkC/NTRK3 Protein, Recombinant

Antibody Products

Molecule Species Description //For Detailed Info. and Price------CLICK!
Human TrkB/NTRK2 WB Mouse Monoclonal Antibody
Human
TrkB/NTRK2
WB, ELISA, IHC TrkB/NTRK2 Antibody, Rabbit MAb
Human TrkB/NTRK2 WB, ELISA Rabbit Polyclonal Antibody
Human TrkB/NTRK2 WB, ELISA, IHC Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human
TrkC/NTRK3
WB, ELISA Mouse Monoclonal Antibody
Human
TrkC/NTRK3
WB, ELISA Rabbit Monoclonal Antibody
Human
TrkC/NTRK3
WB, ELISA Rabbit Polyclonal Antibody
Human
TrkC/NTRK3
WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Mouse
TrkC/NTRK3
WB, ELISA TrkC/NTRK3 Antibody, Rabbit PAb
Mouse
TrkC/NTRK3
WB, ELISA TrkC/NTRK3 Antibody, Rabbit PAb (Antigen Affinity Purified)

cDNA Clone Products

Molecule Species Description //For Detailed Info. and Price------CLICK!
BDNF Human Homo sapiens BDNF transcript variant 4 cDNA Clone(NM_001709.3)
Neurotrophin-3/NT-3 Human Homo sapiens Neurotrophin-3/NT-3 transcript variant2 cDNA Clone(NM_002527.4)
Neurotrophin-4/NT-4 Human Homo sapiens NT-4 cDNA Clone(NM_006179.4)
TrkB/NTRK2 Human Homo sapiens TrkB/NTRK2 transcript variant b cDNA Clone(NM_001007097.1)
TrkB/NTRK2 Mouse Mus musculus TrkB/NTRK2 cDNA Clone
TrkC/NTRK3 Human Homo sapiens TrkC/NTRK3 transcript variant 3 cDNA Clone(NM_001007156.1)
TrkC/NTRK3 Mouse Mus musculus TrkC/NTRK3 cDNA Clone

TrkA / NTRK1 Background

TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors. The presence of NTRK1 leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. It was originally identified as an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas. TRKA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. NTRK1 has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. It also activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway. Defects in NTRK1 are a cause of congenital insensitivity to pain with anhidrosis and thyroid papillary carcinoma.

TrkA / NTRK1 Related Studies

  1. Lambiase A, et al. (2005) Molecular basis for keratoconus: lack of TrkA expression and its transcriptional repression by Sp3. Natl Acad Sci. 102 (46):16795-800.
  2. Benito-Gutiérrez E, et al. (2006) Origin and evolution of the Trk family of neurotrophic receptors. Mol Cell Neurosci. 31(2):179-92.
  3. Martin-Zanca D, et al. (1986) A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature. 319(6056):743-8.

Neurotrophin & Neurotrophin Receptor

   
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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