Anti-TrkA Antibody

Cat: 11073-R024
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Anti-TrkA Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-TrkA Antibody
Validated applications
IHC-P
Species reactivity
Reacts with: Human
Specificity
Human TrkA
Immunogen
Recombinant Human TrkA / NTRK1 protein (Catalog#11073-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human TrkA / NTRK1 (rh TrkA / NTRK1; Catalog#11073-H08H; NP_002520.2; Met 1-Pro 382).
Source
Monoclonal Rabbit IgG Clone #024
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-TrkA Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
IHC-P 1:100-1:500  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-TrkA Antibody (Rabbit Monoclonal antibody) Images
Human TrkA/NTRK1 Immunohistochemistry(IHC) 3837
Immunochemical staining of human NTRK1 in human brain with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Anti-TrkA Antibody Alternative Names
Anti-MTC Antibody;Anti-p140-TrkA Antibody;Anti-TRK Antibody;Anti-Trk-A Antibody;Anti-TRK1 Antibody;Anti-TRKA Antibody
TrkA Background Information

TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors. The presence of NTRK1 leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. It was originally identified as an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas. TRKA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. NTRK1 has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. It also activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway. Defects in NTRK1 are a cause of congenital insensitivity to pain with anhidrosis and thyroid papillary carcinoma.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
neurotrophic tyrosine kinase, receptor, type 1
References
  • Lambiase A, et al. (2005) Molecular basis for keratoconus: lack of TrkA expression and its transcriptional repression by Sp3. Natl Acad Sci. 102 (46):16795-800.
  • Benito-Gutiérrez E, et al. (2006) Origin and evolution of the Trk family of neurotrophic receptors. Mol Cell Neurosci. 31(2):179-92.
  • Martin-Zanca D, et al. (1986) A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature. 319(6056):743-8.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-TrkA Antibody Rabbit Polyclonal ELISA 70101-RP01
    Anti-TrkA Antibody Rabbit Polyclonal ELISA 70101-T16
    Anti-TrkA Antibody Rabbit Polyclonal ELISA 80404-RP01
    Anti-TrkA Antibody Rabbit Polyclonal ELISA,IHC-P 80404-T24
    Anti-TrkA Antibody Rabbit Polyclonal ELISA,IHC-P 51103-T24
    Anti-TrkA Antibody Rabbit Polyclonal ELISA 51103-RP01
    Anti-TrkA Antibody Rabbit Polyclonal ELISA 51103-T16
    Anti-TrkA Antibody Mouse Monoclonal ELISA 11073-MM04
    Anti-TrkA Antibody Rabbit Polyclonal ELISA 11073-RP02
    Anti-TrkA Antibody Mouse Monoclonal ELISA(Cap) 11073-MM02
    Anti-TrkA Antibody Rabbit Monoclonal ELISA 11073-R001
    Anti-TrkA Antibody Rabbit Polyclonal ELISA 11073-RP01
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