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TrkA / NTRK1 Antibody, Rabbit MAb

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Human TrkA/NTRK1 Antibody Product Information
Immunogen:Recombinant Human NTRK1 protein (Catalog#11073-H08H)
Clone ID:1
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human NTRK1 / Trk-A (rh NTRK1; Catalog#11073-H08H; NP_002520.2; Met 1-Pro 382).
Human TrkA/NTRK1 Antibody Usage Guide
Specificity:Human NTRK1 / Trk-A
No cross-reactivity in ELISA with
Human NTRK2 / TrkB
Human NTRK3 / TrKC
Application:ELISA

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human NTRK1. The detection limit for Human NTRK1 is 0.00245 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other TrkA/NTRK1 Antibody Products
Reactivity: Human  
Application: ELISA  
    11073-RP01-100
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    11073-RP01-400
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    Reactivity: Human  
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      11073-RP02-50
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      Reactivity: Human  
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        11073-MM04-50
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        Reactivity: Human  
        Application: IHC-P  
        • Slide 1
        11073-R024-50
        11073-R024-100
        50 µg 
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        Reactivity: Mouse  
        Application: ELISA  
          51103-T16-50
          51103-T16-100
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          Reactivity: Mouse  
          Application: ELISA  
            51103-RP01-400
            51103-RP01-200
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            Reactivity: Rat  
            Application: ELISA  
              80404-RP01-400
              80404-RP01-200
              80404-RP01-100
               
              200 µg 
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              Reactivity: Rat  
              Application: ELISA  IHC-P  
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              80404-T24-200
              80404-T24-100
              80404-T24-50
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              Reactivity: Canine  
              Application: ELISA  
                70101-T16-200
                70101-T16-50
                70101-T16-100
                200 µg 
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                Reactivity: Canine  
                Application: ELISA  
                  70101-RP01-400
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                  70101-RP01-100
                   
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                  TrkA/NTRK1 Background

                  TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors. The presence of NTRK1 leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. It was originally identified as an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas. TRKA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. NTRK1 has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. It also activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway. Defects in NTRK1 are a cause of congenital insensitivity to pain with anhidrosis and thyroid papillary carcinoma.

                  Human TrkA/NTRK1 References
                • Lambiase A, et al. (2005) Molecular basis for keratoconus: lack of TrkA expression and its transcriptional repression by Sp3. Natl Acad Sci. 102 (46):16795-800.
                • Benito-Gutiérrez E, et al. (2006) Origin and evolution of the Trk family of neurotrophic receptors. Mol Cell Neurosci. 31(2):179-92.
                • Martin-Zanca D, et al. (1986) A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature. 319(6056):743-8.
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                  Size / Price
                  Catalog: 11073-R001-50
                  List Price: 
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                  Size:
                  50 µg
                  100 µg
                  Quantity:+-
                  AvailabilityIn Stock
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                  All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                  Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"