Anti-TrkA Antibody

Cat: 11073-R001

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Anti-TrkA Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-TrkA Antibody
Validated applications
Species reactivity
Reacts with: Human
Human TrkA
No cross-reactivity in ELISA with Human NTRK2 / TrkB Human NTRK3 / TrKC
Recombinant Human NTRK1 protein (Catalog#11073-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human NTRK1 / Trk-A (rh NTRK1; Catalog#11073-H08H; NP_002520.2; Met 1-Pro 382).
Monoclonal Rabbit IgG Clone #1
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-TrkA Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-TrkA Antibody Alternative Names
Anti-MTC Antibody;Anti-p140-TrkA Antibody;Anti-TRK Antibody;Anti-Trk-A Antibody;Anti-TRK1 Antibody;Anti-TRKA Antibody
TrkA Background Information

TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors. The presence of NTRK1 leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. It was originally identified as an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas. TRKA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. NTRK1 has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. It also activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway. Defects in NTRK1 are a cause of congenital insensitivity to pain with anhidrosis and thyroid papillary carcinoma.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
neurotrophic tyrosine kinase, receptor, type 1
  • Lambiase A, et al. (2005) Molecular basis for keratoconus: lack of TrkA expression and its transcriptional repression by Sp3. Natl Acad Sci. 102 (46):16795-800.
  • Benito-Gutiérrez E, et al. (2006) Origin and evolution of the Trk family of neurotrophic receptors. Mol Cell Neurosci. 31(2):179-92.
  • Martin-Zanca D, et al. (1986) A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature. 319(6056):743-8.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-TrkA Antibody Rabbit Polyclonal ELISA 70101-RP01
    Anti-TrkA Antibody Rabbit Polyclonal ELISA 70101-T16
    Anti-TrkA Antibody Rabbit Polyclonal ELISA 80404-RP01
    Anti-TrkA Antibody Rabbit Polyclonal ELISA,IHC-P 80404-T24
    Anti-TrkA Antibody Rabbit Polyclonal ELISA,IHC-P 51103-T24
    Anti-TrkA Antibody Rabbit Polyclonal ELISA 51103-RP01
    Anti-TrkA Antibody Rabbit Polyclonal ELISA 51103-T16
    Anti-TrkA Antibody Mouse Monoclonal ELISA 11073-MM04
    Anti-TrkA Antibody Rabbit Polyclonal ELISA 11073-RP02
    Anti-TrkA Antibody Rabbit Monoclonal IHC-P 11073-R024
    Anti-TrkA Antibody Rabbit Polyclonal ELISA 11073-RP01
    Anti-TrkA Antibody Mouse Monoclonal ELISA(Cap) 11073-MM02
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