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TrkA / NTRK1 Antibody, Rabbit PAb

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    Human TrkA/NTRK1 Antibody Product Information
    Immunogen:Recombinant Human NTRK1 protein (Catalog#11073-H08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Human NTRK1 / Trk-A (rh NTRK1; Catalog#11073-H08H; NP_002520.2; Met 1-Pro 382). Total IgG was purified by Protein A affinity chromatography.
    Other TrkA/NTRK1 Antibody Products
    Reactivity: Human  
    Application: IHC-P  
    • Slide 1
    11073-R024-50
    11073-R024-100
    50 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: 
      11073-MM02-50
      11073-MM02-200
      11073-MM02-100
      11073-MM02-1
      50 µg 
      200 µg 
      100 µg 
      1 mg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        11073-MM04-50
        11073-MM04-200
        11073-MM04-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          11073-R001-50
          11073-R001-100
          50 µg 
          100 µg 
          Add to Cart
          Reactivity: Human  
          Application: ELISA  
            11073-RP02-50
            11073-RP02-200
            11073-RP02-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  
              51103-RP01-400
              51103-RP01-200
              51103-RP01-100
              400 µg 
              200 µg 
              100 µg 
              Add to Cart
              Reactivity: Mouse  
              Application: ELISA  
                51103-T16-50
                51103-T16-200
                51103-T16-100
                50 µg 
                200 µg 
                100 µg 
                Add to Cart
                Reactivity: Rat  
                Application: ELISA  IHC-P  
                • Slide 1
                • Slide 1
                80404-T24-50
                80404-T24-200
                80404-T24-100
                50 µg 
                200 µg 
                100 µg 
                Add to Cart
                Reactivity: Rat  
                Application: ELISA  
                  80404-RP01-400
                  80404-RP01-200
                  80404-RP01-100
                  400 µg 
                  200 µg 
                  100 µg 
                  Add to Cart
                  Reactivity: Canine  
                  Application: ELISA  
                    70101-RP01-400
                    70101-RP01-200
                    70101-RP01-100
                    400 µg 
                    200 µg 
                    100 µg 
                    Add to Cart
                    Reactivity: Canine  
                    Application: ELISA  
                      70101-T16-50
                      70101-T16-200
                      70101-T16-100
                      50 µg 
                      200 µg 
                      100 µg 
                      Add to Cart
                      TrkA/NTRK1 Background

                      TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors. The presence of NTRK1 leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. It was originally identified as an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas. TRKA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. NTRK1 has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. It also activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway. Defects in NTRK1 are a cause of congenital insensitivity to pain with anhidrosis and thyroid papillary carcinoma.

                      Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                      Human TrkA/NTRK1 References
                    • Lambiase A, et al. (2005) Molecular basis for keratoconus: lack of TrkA expression and its transcriptional repression by Sp3. Natl Acad Sci. 102 (46):16795-800.
                    • Benito-Gutiérrez E, et al. (2006) Origin and evolution of the Trk family of neurotrophic receptors. Mol Cell Neurosci. 31(2):179-92.
                    • Martin-Zanca D, et al. (1986) A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature. 319(6056):743-8.
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                      Catalog: 11073-RP01-100
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                      Datasheet & Documentation

                      All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"