Transforming Growth Factor Beta (TGF-beta) Superfamily

Sino biological offers a comprehensive set of tools for transforming growth factor beta (TGF-beta) superfamily related studies.

Product Categories / Species	Human	Mouse	Rat
Recombinant Proteins	38	12	1
Antibodies	15	3	-
ORF cDNA Clones	55	17	1

Transforming Growth Factor Beta (TGF-beta) Superfamily Products Index

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Activin/Inhibin	TGF-beta Family
BMP (Bone Morphogenetic Protein) Family	TGF-beta Superfamily Modulators
GDF (Growth Differentiation Factor) Family	TGF-beta Superfamily Receptors
GDNF (Glial cell line-Derived Neurotrophic Factor) Family	Other TGF-beta Superfamily Ligands

Activin A^*	BMPR2	Inhibin beta B / INHBB
Activin B^*	CER2 / DAND5^*	Inhibin beta C / INHBC^*
Activin C^*	Cerberus 1^*	Inhibin beta E / INHBE^*
ACVR1 / ALK-2	Chordin-Like 1 / CHRDL1	Lefty2 / Lefty A
ACVR1B / ALK-4	Cripto / TDGF1	NBL1 / DAND1
ACVR2A	Decorin	NCAM1 / CD56^*
ACVR2B	Endoglin / CD105	Neurturin^*
ALK-1 / ACVRL1	FLRG / FSTL3	Noggin
ALK-7^*	Follistatin^*	Persephin^*
Artemin^*	FSTL1 / Follistatin-like 1	Sclerostin / SOST
BAMBI / NMA	GDF-1^*	Smad1^*
BMP-2	GDF-2 / BMP-9^*	Smad2^*
BMP-2a^*	GDF-3^*	Smad3^*
BMP-3^*	GDF-5^*	Smad4^*
BMP-3b / GDF-10^*	GDF-6^*	Smad5^*
BMP-4^*	GDF-9^*	TGF-beta 1
BMP-5	GDF-10 / BMP-3b^*	TGF-beta 2^*
BMP-6^*	GDF-15	TGF-beta 3^*
BMP-7^*	GDNF^*	TGF-beta 5^*
BMP-8^*	GFRA1	TGFBR1 / ALK-5
BMP-8a^*	GFRA2	TGFBR2
BMP-9 / GDF-2^*	GFRA3	TGFBR3^*
BMP-10^*	GFRA4^*	TMEFF1 / Tomoregulin-1^*
BMPR1A / ALK-3 / CD292	Inhibin alpha / INHA^*	Tsukushin / TSK^*
BMPR1B / ALK-6 / CDw293^*	Inhibin beta A / INHBA

Transforming Growth Factor Beta (TGF-beta) Superfamily Background

The transforming growth factor beta 1 (TGF-beta 1) is the first member of the TGF-beta superfamily that is comprised of a large group of proteins, including the activin/inhibin family, Bone morphogenetic proteins (BMPs), growth/differentiation factors (GDFs) and the TGF-beta subfamily. Members of the TGF-beta superfamily interact with a conserved family of cell surface serine/threonine-specific protein kinase receptors to activate Smad signaling cascades. TGF-beta superfamily members play fundamental roles in the regulation of various biological processes such as growth, development, tissue homeostasis and regulation of the immune system.

Transforming Growth Factor Beta (TGF-beta) Superfamily Related Studies

Herpin A, et al. (2004) Transforming growth factor-beta-related proteins: an ancestral and widespread superfamily of cytokines in metazoans". Dev Comp Immunol. 28 (5): 461–85.
Mukhopadhyay P,et al. (2006) Expression profiling of transforming growth factor beta superfamily genes in developing orofacial tissue. Birth Defects Res A Clin Mol Teratol. 76(7):528-43.
Kollias HD, et al. (2008) Transforming growth factor-beta and myostatin signaling in skeletal muscle. J Appl Physiol. 104(3):579-87.
Trombly DJ, et al. (2009) Roles for transforming growth factor beta superfamily proteins in early folliculogenesis. Semin Reprod Med. 27(1):14-23.